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Bifunctional
tetrahydrofolate
synthase/dihydrofolate
synthase
GTP
cyclohydrolase
1 1
Unknown
7,8-
dihydroneopterin
aldolase
2-amino-4-
hydroxy-6-
hydroxymethyldihydropteridine
pyrophosphokinase
Dihydropteroate
synthase type-1
Aminodeoxychorismate
lyase
Anthranilate
synthase
component 1
Anthranilate
synthase
component 2
KR domain
protein
Tetrahydrofolic
acid
Guanosine
triphosphate
Chorismate
H
2
O
Formic acid
H
+
7,8-
dihydroneopterin
3'-triphosphate
H
2
O
PP
i
H
+
7,8-
dihydroneopterin
3'-phosphate
H
2
O
P
i
7,8-
Dihydroneopterin
Glycolaldehyde
6-
hydroxymethyl-
7,8-
dihydropterin
ATP
AMP
H
+
(2-amino-4-
hydroxy-7,8-
dihydropteridin-
6-yl)methyl
diphosphate
p-Aminobenzoic
acid
PP
i
7,8-
Dihydropteroic
acid
4-amino-4-
deoxychorismate
Pyruvic acid
H
+
L-Glutamine
L-Glutamic acid
ATP
L-Glutamic acid
ADP
P
i
H
+
7,8-
dihydrofolate
monoglutamate
H
+
NADPH
NADP
Magnesium
Magnesium
Potassium
Magnesium
One Carbon Pool
by Folate
Purine
Nucleotides De
Novo
Biosynthesis
Chorismate
Biosynthesis
Dihydrofolate
reductase
Magnesium
HV87_25995
folE1
Unknown
folB_2
folK
sulI
HV87_26270
trpE
trpG
CSB93_2854
Tetrahydrofolic
acid
Guanosine
triphosphate
Chorismate
Water
Formic acid
Hydrogen Ion
7,8-
dihydroneopterin
3'-triphosphate
Water
Pyrophosphate
Hydrogen Ion
7,8-
dihydroneopterin
3'-phosphate
Water
Phosphate
7,8-
Dihydroneopterin
Glycolaldehyde
6-
hydroxymethyl-
7,8-
dihydropterin
Adenosine
triphosphate
Adenosine
monophosphate
Hydrogen Ion
(2-amino-4-
hydroxy-7,8-
dihydropteridin-
6-yl)methyl
diphosphate
p-Aminobenzoic
acid
Pyrophosphate
7,8-
Dihydropteroic
acid
4-amino-4-
deoxychorismate
Pyruvic acid
Hydrogen Ion
L-Glutamine
L-Glutamic acid
Adenosine
triphosphate
L-Glutamic acid
Adenosine
diphosphate
Phosphate
Hydrogen Ion
7,8-
dihydrofolate
monoglutamate
Hydrogen Ion
NADPH
NADP
One Carbon Pool
by Folate
Purine
Nucleotides De
Novo
Biosynthesis
Chorismate
Biosynthesis
dhfrIII_2