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Amidophosphoribosyltransferase
Phosphoribosylamine-
-glycine ligase
Formate-
dependent
phosphoribosylglycinamide
formyltransferase
Phosphoribosylformylglycinamidine
synthase
Phosphoribosylformylglycinamidine
cyclo-ligase
N5-
carboxyaminoimidazole
ribonucleotide
synthase
N5-
carboxyaminoimidazole
ribonucleotide
mutase
Phosphoribosylaminoimidazole-
succinocarboxamide
synthase
Adenylosuccinate
lyase
Inosine-5'-
monophosphate
dehydrogenase
Adenylosuccinate
synthetase
Adenylosuccinate
lyase
GMP synthase
[glutamine-
hydrolyzing]
Guanylate
kinase
Nucleoside
diphosphate
kinase
Ribonucleoside-
diphosphate
reductase
subunit beta
Nucleoside
diphosphate
kinase
Ribonucleoside-
diphosphate
reductase
Ribonucleoside-
diphosphate
reductase
subunit beta
Nucleoside
diphosphate
kinase
Bifunctional
purine
biosynthesis
protein PurH
Cob(I)yrinic
acid
a,c-diamide
adenosyltransferase
Unknown
Unknown
Bifunctional
purine
biosynthesis
protein PurH
Anaerobic
ribonucleoside-
triphosphate
reductase
Ribonucleoside-
diphosphate
reductase
subunit beta
Adenylate
kinase
ATP synthase
subunit c
ATP synthase
subunit b
ATP synthase
subunit a
ATP synthase
epsilon chain
ATP synthase
subunit delta
ATP synthase
subunit alpha
ATP synthase
gamma chain
ATP synthase
subunit beta
Anaerobic
ribonucleoside-
triphosphate
reductase
Anaerobic
ribonucleoside-
triphosphate
reductase
Ribonucleoside-
diphosphate
reductase
subunit beta
Guanosine
triphosphate
Phosphoribosyl
pyrophosphate
H
2
O
L-Glutamine
5-
Phosphoribosylamine
L-Glutamic acid
PP
i
Glycine
ATP
N1-(5-
phospho-β-D-
ribosyl)glycinamide
P
i
ADP
H
+
ATP
Formic acid
5'-
Phosphoribosyl-
N-
formylglycinamide
ADP
P
i
H
+
H
2
O
L-Glutamine
ATP
2- (Formamido)-
N1-(5-
phospho-D-
ribosyl)acetamidine
L-Glutamic acid
P
i
ADP
H
+
ATP
5-
Aminoimidazole
ribonucleotide
P
i
ADP
H
+
HCO
3
-
ATP
N5-
Carboxyaminoimidazole
ribonucleotide
ADP
P
i
H
+
5-amino-1-(5-
phospho-D-
ribosyl)imidazole-
4-carboxylate
L-Aspartic acid
ATP
SAICAR
P
i
ADP
H
+
AICAR
Fumaric acid
Inosinic acid
NAD
H
2
O
NADH
H
+
Xanthylic acid
L-Aspartic acid
GTP
GDP
P
i
H
+
N(6)-(1,2-
dicarboxyethyl)AMP
Fumaric acid
Adenosine
monophosphate
ATP
L-Glutamine
H
2
O
AMP
PP
i
L-Glutamic acid
H
+
Guanosine
monophosphate
ATP
ADP
Guanosine
diphosphate
ATP
ADP
H
2
O
dGDP
ATP
ADP
dGTP
Adenosine
diphosphate
H
2
O
dADP
ATP
ADP
dATP
10-
Formyltetrahydrofolate
FAICAR
tetrahydropteroyl
mono-L-
glutamate
Adenosine
triphosphate
Cobalamin
Triphosphate
Adenosylcobalamin
Itaconic acid
CoA
ADP
P
i
Itaconyl-CoA
H
2
O
H
2
O
ATP
P
i
H
+
H
2
O
H
+
H
2
O
H
2
O
H
2
O
Magnesium
Magnesium
Potassium
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
Adenosine
triphosphate
dGTP
Thymidine
5'-triphosphate
Potassium
Magnesium
4Fe-4S
Adenosine
triphosphate
dGTP
Thymidine
5'-triphosphate
Potassium
Magnesium
Zinc (II) ion
4Fe-4S
reduced
thioredoxin
oxidized
thioredoxin
a reduced NrdH
glutaredoxin-
like protein
an oxidized
NrdH
glutaredoxin-
like protein
reduced
thioredoxin
oxidized
thioredoxin
a reduced
flavodoxin
an oxidized
flavodoxin
a reduced
flavodoxin
an oxidized
flavodoxin
a reduced NrdH
glutaredoxin-
like protein
an oxidized
NrdH
glutaredoxin-
like protein
Folate
Biosynthesis
PRPP
Biosynthesis