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ATP
phosphoribosyltransferase
Histidine
biosynthesis
bifunctional
protein HisIE
Histidine
biosynthesis
bifunctional
protein HisIE
1-(5-
phosphoribosyl)-
5-[(5-
phosphoribosylamino)methylideneamino]
imidazole-4-
carboxamide
isomerase
Histidine
biosynthesis
bifunctional
protein HisB
Histidinol-
phosphate
aminotransferase
Histidine
biosynthesis
bifunctional
protein HisB
Histidinol
dehydrogenase
Histidinol
dehydrogenase
Imidazole
glycerol
phosphate
synthase
subunit HisH 2
Imidazole
glycerol
phosphate
synthase
subunit HisF
L-Histidine
Phosphoribosyl
pyrophosphate
H
+
PP
i
Phosphoribosyl-
ATP
H
2
O
H
+
PP
i
Phosphoribosyl-
AMP
H
2
O
1-(5'-
Phosphoribosyl)-
5-amino-4-
imidazolecarboxamide
PhosphoribosylformiminoAICAR-
phosphate
D-Erythro-
imidazole-
glycerol-
phosphate
H
2
O
Imidazole
acetol-
phosphate
L-Glutamic acid
Oxoglutaric
acid
L-histidinol-
phosphate
H
2
O
P
i
L-Histidinol
NAD
NADH
H
+
Histidinal
H
2
O
NAD
H
+
NADH
L-Glutamine
5-
Aminoimidazole-
4-carboxamide
H
+
L-Glutamic acid
PRPP
Biosynthesis
hisG_2
hisE_1
hisE_1
hisA_2
hisB_2
hisC
hisB_2
hisD
hisD
hisH2
hisF
L-Histidine
Phosphoribosyl
pyrophosphate
Hydrogen Ion
Pyrophosphate
Phosphoribosyl-
ATP
Water
Hydrogen Ion
Pyrophosphate
Phosphoribosyl-
AMP
Water
1-(5'-
Phosphoribosyl)-
5-amino-4-
imidazolecarboxamide
PhosphoribosylformiminoAICAR-
phosphate
D-Erythro-
imidazole-
glycerol-
phosphate
Water
Imidazole
acetol-
phosphate
L-Glutamic acid
Oxoglutaric
acid
L-histidinol-
phosphate
Water
Phosphate
L-Histidinol
NAD
NADH
Hydrogen Ion
Histidinal
Water
NAD
Hydrogen Ion
NADH
L-Glutamine
5-
Aminoimidazole-
4-carboxamide
Hydrogen Ion
L-Glutamic acid
PRPP
Biosynthesis