PathBank

Pathway Description

Thiosulfate Disproportionation III

Pseudomonas aeruginosa

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2019-08-12

Last Updated: 2019-08-16

Thiosulfate sulfurtransferase (also known as rhodanese) can facilitate the transfer of a sulfur atom from sulfur donors to nucleophilic sulfur acceptors, and it has been found in many major phyla (prokaryotic and eukaryotic). The role of thiosulfate sulfurtransferase might be the detoxification of cyanide in both bacteria and mammals, or it might also involve in formation of prosthetic groups in iron-sulfur proteins. In this pathway, thiosulfate and hydrogen cyanide have been catalyzed by thiosulfate sulfurtransferase to form thiocyanate and sulfite. Sulfite is used in later sulfur metabolism.

References

Thiosulfate Disproportionation III References

Lee DG, Urbach JM, Wu G, Liberati NT, Feinbaum RL, Miyata S, Diggins LT, He J, Saucier M, Deziel E, Friedman L, Li L, Grills G, Montgomery K, Kucherlapati R, Rahme LG, Ausubel FM: Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol. 2006;7(10):R90. doi: 10.1186/gb-2006-7-10-r90. Epub 2006 Oct 12.

Pubmed: 17038190

Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079.

Pubmed: 10984043

Larbig KD, Christmann A, Johann A, Klockgether J, Hartsch T, Merkl R, Wiehlmann L, Fritz HJ, Tummler B: Gene islands integrated into tRNA(Gly) genes confer genome diversity on a Pseudomonas aeruginosa clone. J Bacteriol. 2002 Dec;184(23):6665-80. doi: 10.1128/jb.184.23.6665-6680.2002.

Pubmed: 12426355

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0002072

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine triphosphate
		Hydrogen cyanide
		Hydrogen Ion
		Phosphate
		Sulfite
		Thiocyanate
		Thiosulfate
		Water

Visualize Protein Data

		ABC transporter permease
		dTDP-4-dehydrorhamnose reductase
		Probable 3-mercaptopyruvate sulfurtransferase
		Sulfate transport system permease protein CysT
		Sulfate/thiosulfate import ATP-binding protein CysA
		Sulfate/thiosulfate transporter permease subunit
		Thiosulfate sulfurtransferase GlpE
		Uncharacterized protein ORF C29