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Pathway Description
Hydrogen Sulfide Biosynthesis I
Pseudomonas aeruginosa
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2019-08-12
Last Updated: 2019-08-16
Many bacteria can produce hydrogen sulfide, which can be used as defense system against antibiotics and oxidative stress. This pathway is one of the hydrogen sulfide biosynthesis pathways (totally two). L-Cysteine is transported by L-cysteine ABC transporter and convert to 3-mercaptopyruvic acid by facilitation of aspartate aminotransferase. 3-Mercaptopyruvic acid is later catalyzed to form pyruvic acid and hydrogen sulfide by 3-mercaptopyruvate sulfurtransferase.
References
Hydrogen Sulfide Biosynthesis I References
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079.
Pubmed: 10984043
Rivera E, Vila L, Barbe J: The uvrB gene of Pseudomonas aeruginosa is not DNA damage inducible. J Bacteriol. 1996 Sep;178(18):5550-4. doi: 10.1128/jb.178.18.5550-5554.1996.
Pubmed: 8808952
Nishijyo T, Park SM, Lu CD, Itoh Y, Abdelal AT: Molecular characterization and regulation of an operon encoding a system for transport of arginine and ornithine and the ArgR regulatory protein in Pseudomonas aeruginosa. J Bacteriol. 1998 Nov;180(21):5559-66.
Pubmed: 9791103
Park SM, Lu CD, Abdelal AT: Cloning and characterization of argR, a gene that participates in regulation of arginine biosynthesis and catabolism in Pseudomonas aeruginosa PAO1. J Bacteriol. 1997 Sep;179(17):5300-8. doi: 10.1128/jb.179.17.5300-5308.1997.
Pubmed: 9286980
Yan J, Deforet M, Boyle KE, Rahman R, Liang R, Okegbe C, Dietrich LEP, Qiu W, Xavier JB: Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network. PLoS Comput Biol. 2017 Aug 2;13(8):e1005677. doi: 10.1371/journal.pcbi.1005677. eCollection 2017 Aug.
Pubmed: 28767643
Zhao GS, Xia TH, Fischer RS, Jensen RA: Cyclohexadienyl dehydratase from Pseudomonas aeruginosa. Molecular cloning of the gene and characterization of the gene product. J Biol Chem. 1992 Feb 5;267(4):2487-93.
Pubmed: 1733946
Zhao G, Xia T, Aldrich H, Jensen RA: Cyclohexadienyl dehydratase from Pseudomonas aeruginosa is a periplasmic protein. J Gen Microbiol. 1993 Apr;139(4):807-13. doi: 10.1099/00221287-139-4-807.
Pubmed: 8515238
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0002078
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