PathBank

Pathway Description

Methylglyoxal Degradation IV

Pseudomonas aeruginosa

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2019-08-12

Last Updated: 2019-09-15

Methylglyoxal, also known as pyruvaldehyde, is a cytotoxic compound derived from pyruvic acid. In E. coli, there are at least eight pathways that are responsible for the detoxification of methylglyoxal. The first reaction in this pathway is the reduction of pyruvaldehyde to (S)-lactaldehyde, along with the cofactor NADH, catalyzed by 2,5-diketo-D-gluconic acid reductase subunits A and B. Following this, (S)-lactaldehyde is dehydrogenated into L-lactic acid by the lactaldehyde dehydrogenase enzyme, also using NAD as a cofactor. Finally, L-lactic acid is converted to pyruvic acid by L-lactate dehydrogenase in a reaction involving the reduction of an electron acceptor. Pyruvic acid is then used in glycolysis and pyruvate dehydrogenase pathways.

References

Methylglyoxal Degradation IV References

Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079.

Pubmed: 10984043

Yamanishi Y, Mihara H, Osaki M, Muramatsu H, Esaki N, Sato T, Hizukuri Y, Goto S, Kanehisa M: Prediction of missing enzyme genes in a bacterial metabolic network. Reconstruction of the lysine-degradation pathway of Pseudomonas aeruginosa. FEBS J. 2007 May;274(9):2262-73. doi: 10.1111/j.1742-4658.2007.05763.x. Epub 2007 Mar 27.

Pubmed: 17388807

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0002090

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