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Pathway Description
Lymecycline Anti-Bacterial Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2021-03-16
Last Updated: 2023-10-25
Lymecycline is a broad-spectrum second-generation tetracycline antibiotic that is used for the treatment of acne and other bacterial infections. Lymecycline is administered orally or intramuscular/intravenous and travels through the blood stream to the site of infection where it inhibits the subunit 30S ribosomal protein S4 of ribosomes.
Lymecycline, like other tetracyclines, exerts bacteriostatic actions on intracellular and extracellular bacteria, treating susceptible bacterial infections.9 It has been shown to be safe and effective in the treatment of moderate to severe acne. A caution when using is that lymecycline may cause esophageal irritation and ulceration. This can be prevented by drinking adequate fluids during administration. It also has the potential to cause photosensitivity and lead to renal tubular acidosis or hepatic toxicity. Patients with renal disease or severe hepatic disease should not be given this drug.
References
Lymecycline Anti-Bacterial Pathway References
Song, K.S. Ribosomal protein synthesis inhibitors. In S. Offermanns, & W. Rosenthal (Eds.). Encyclopedic reference of molecular pharmacology. (2004) p. 827-833. Berlin, Germany: Springer.
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
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