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Pathway Description
Spectinomycin Anti-bacterial Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2021-05-10
Last Updated: 2023-10-25
Spectinomycin is an aminocyclitol antibiotic used to treat susceptible strains of gram-negative bacteria, Neisseria gonorrhoeae. It is used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium Streptomyces spectabilis. Spectinomycin is an inhibitor of protein synthesis in the bacterial cell by binding to the 30S ribosomal subunit. As a result, this agent interferes with the initiation of protein synthesis and with proper protein elongation. This eventually leads to bacterial cell death.
References
Spectinomycin Anti-bacterial Pathway References
National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 15541, Spectinomycin. Retrieved September 1, 2021 from https://pubchem.ncbi.nlm.nih.gov/compound/Spectinomycin.
Wishart, D., Knox, C., Guo, A., Shrivastava, S., Hassanali, M., Stothard, P., . . . Woolsey, J. (2005, June). Abacavir. Retrieved August 23, 2021, from https://go.drugbank.com/drugs/DB00919
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