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ATP-binding cassette sub-family C member 8 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Solute carrier family 2, facilitated glucose transporter member 2 Insulin Insulin Glimepiride ATP K+ D-Glucose K+ Ca+ Ca+ D-Glucose D-Glucose Glycolysis Oxidative Phosphorylation (Homo Sapiens Pancreas beta cell Pancreatic Islet Depolarization ΔVm Insulin secretion ↓ Glucose concentration decreases ↑ Increased glucose concentration ↑ ATP concentration increases Mitochondria ↑ Influx of calcium ions causes an increase in Insulin secretion ATP inhibits the ATP-sensitive K+ pump by causing a conformational change causing the potassium pore to close Glimepiride also acts as a K+ channel inhibitor and directly closes ATP-sensitive K+ channels Reduced K+ efflux causes depolarization of the membrane Reduced membrane potential activates voltage-gated Ca2+ channels ATP synthesis through glycolysis and mitochondrial respiration ↑ Glucose concentration causes ↑ ATP synthesis Cytosol
ABCC8 CACNA1A CACNB1 CACNA2D2 SLC2A2 Unknown Unknown Glimepiride Adenosine triphosphate Potassium D-Glucose Potassium Calcium Calcium D-Glucose D-Glucose Glycolysis Oxidative Phosphorylation (Homo Sapiens
ABCC8 CACNA1A CACNB1 CACNA2D2 SLC2A2 Amaryl ATP K+ D-Glc K+ Ca+ Ca+ D-Glc D-Glc PW000146 O P H S Pancreas beta cell Pancreatic Islet Depolarization ΔVm Insulin secretion ↓ Glucose concentration decreases ↑ Increased glucose concentration ↑ ATP concentration increases Mitochondria ↑ Influx of calcium ions causes an increase in Insulin secretion ATP inhibits the ATP-sensitive K+ pump by causing a conformational change causing the potassium pore to close Glimepiride also acts as a K+ channel inhibitor and directly closes ATP-sensitive K+ channels Reduced K+ efflux causes depolarization of the membrane Reduced membrane potential activates voltage-gated Ca2+ channels ATP synthesis through glycolysis and mitochondrial respiration ↑ Glucose concentration causes ↑ ATP synthesis Cytosol
ABCC8 CACNA1A CACNB1 CACNA2D2 SLC2A2 Amaryl ATP K+ D-Glc K+ Ca2+ Ca2+ D-Glc D-Glc PW000146 O P H S