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Pathway Description
Clomocycline Anti-Bacterial Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2022-01-19
Last Updated: 2023-10-25
Clomocycline is a tetracycline used to treat bacterial infections. It is used for the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection; chronic bronchitis.
Clomocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Clomocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
References
Clomocycline Anti-Bacterial Pathway References
Sandman Z, Iqbal OA: Azithromycin
Pubmed: 32491698
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
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