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P-glycoprotein ATP-dependent translocase ABCB1 Multidrug resistance associated protein Solute carrier organic anion transporter family member 2B1 Carboxylesterase 1A1 Ritalinic acid Methylphenidate Methylphenidate Methylphenidate Methylphenidate Ritalinic acid Renal excretion Methylphenidate is taken orally in the form of a pill 60%-86% is metabolized in the liver into Ritalinic acid and secreted as such. 78%-97% is excreted renally with the majority of that being Ritalinic acid. Very small traces of Methylphenidate is detected in the urine. Methylphenidate can diffuse through many membranes, but P-glycoprotein has been found to help transport the drug some of the time. Intestinal Epithelial Cell Intestinal Lumen Blood Vessel Hepatocyte
ABCB1 ABCB1 MRP3 SLCO2B1 CES1A1 Ritalinic acid Methylphenidate Methylphenidate Methylphenidate Methylphenidate Ritalinic acid Renal excretion
ABCB1 ABCB1 MRP3 SLCO2B1 CES1A1 RA Phenidy Phenidy Phenidy Phenidy RA Ren exc Methylphenidate is taken orally in the form of a pill 60%-86% is metabolized in the liver into Ritalinic acid and secreted as such. 78%-97% is excreted renally with the majority of that being Ritalinic acid. Very small traces of Methylphenidate is detected in the urine. Methylphenidate can diffuse through many membranes, but P-glycoprotein has been found to help transport the drug some of the time. Intestinal Epithelial Cell Intestinal Lumen Blood Vessel Hepatocyte
ABCB1 ABCB1 MRP3 SLCO2B1 CES1A1 RA Phenidy Phenidy Phenidy Phenidy RA Ren exc