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Cocaine Cocaine Cocaine Na+ Na+ Na+ Na+ Na+ Sodium channel subunit beta-1 Sodium channel subunit beta-1 Sodium channel protein type 10 subunit alpha Sodium channel subunit beta-1 Sodium channel protein type 10 subunit alpha Sodium channel protein type 10 subunit alpha Na+ Cytosol Stimulation through touch, pressure, stretch, or pain Stimulation from touch, pressure, stretch, or pain causes sodium channels on sensory receptors to open. Cocaine inhibits those channels, preventing the sensory receptor from depolarizing and triggering an action potential. The inhibition of sodium channels on sensory neurons prevents signals of touch, pressure, stretch, or pain which causes an anesthesic effect Sensory Neuron Sensory Neurons
Cocaine Cocaine Cocaine Sodium Sodium Sodium Sodium Sodium SCN1B SCN1B SCN10A SCN1B SCN10A SCN10A Sodium
Cocaine Cocaine Cocaine Na+ Na+ Na+ Na+ Na+ SCN1B SCN1B SCN10A SCN1B SCN10A SCN10A Na+ Cytosol Stimulation through touch, pressure, stretch, or pain Stimulation from touch, pressure, stretch, or pain causes sodium channels on sensory receptors to open. Cocaine inhibits those channels, preventing the sensory receptor from depolarizing and triggering an action potential. The inhibition of sodium channels on sensory neurons prevents signals of touch, pressure, stretch, or pain which causes an anesthesic effect Sensory Neuron Sensory Neurons
Cocaine Cocaine Cocaine Na+ Na+ Na+ Na+ Na+ SCN1B SCN1B SCN10A SCN1B SCN10A SCN10A Na+