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IRF3
IRF3
IRF3
TLR2
NFKB1
TLR4
IRF3
STAT1
IRF3
IFNAR1
IFNAR2
IFNB1
NOS2
TNF
IL6
IL1B
ACOD1
CRH
ACOD1
Succinate
dehydrogenase
[ubiquinone]
flavoprotein
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
iron-sulfur
subunit,
mitochondrial
Succinate
dehydrogenase
cytochrome b560
subunit,
mitochondrial
Succinate
dehydrogenase
EGLN2
HIF1A
SLC2A1
IL1B
TLR9
TICAM1
IRF3
MYD88
NFKB1
TLR3
MYD88
TICAM1
TLR7
MYD88
TICAM1
IRF7
NFKB1
IRF7
NFKB1
IRF7
HK2
IL1B
IL1B
IL1B
IL6
IFNAR1
IFNAR2
IFNB1
TNF
NOS2
Solute carrier
family 2,
facilitated
glucose
transporter
member 2
Solute carrier
family 22
member 5
Solute carrier
family 13
member 3
Solute carrier
family 2,
facilitated
glucose
transporter
member 1
Monocarboxylate
transporter 4
Histone H4
Importin-4
IL1B
Interleukin
enhancer-
binding factor
3
Exportin-5
Low affinity
cationic amino
acid
transporter 2
Solute carrier
family 22
member 8
Solute carrier
family 22
member 2
Solute carrier
family 22
member 2
Solute carrier
family 22
member 8
Interleukin
Transport
IL6
IL1B
TNF
IFNAR1
IFNAR2
IFNB1
IL1B
IL1B
IL6
IL6
TNF
TNF
NOS2
PKM
PKM
PKM
Tetrahydrobiopterin
MYD88
TICAM2
IRF7
Flavin
Mononucleotide
Flavin
Mononucleotide
Tetrahydrobiopterin
TICAM1
PKM
Adrenocorticotropic hormone
Adrenocorticotropic hormone
Cortisol
Epinephrine
D-Glucose
L-Lactic acid
NO
Citric acid
L-Acetylcarnitine
D-Glucose
D-Glucose
L-Acetylcarnitine
L-Acetylcarnitine
NO
NO
Succinic acid
Succinic acid
L-Lactic acid
L-Arginine
L-Arginine
Cortisol
Epinephrine
Epinephrine
Cortisol
H
+
NADPH
O
2
L-Arginine
Citrulline
NADP
H
2
O
Q
FAD
Fumaric acid
QH
2
FADH
2
H
+
NADPH
O
2
Citrulline
NADP
H
2
O
NO
L-Threonine
L-Lysine
L-Tryptophan
L-Leucine
L-Isoleucine
L-Valine
L-Arginine
Glycine
L-Serine
Heme
FAD
2Fe-2S
Heme
FAD
Flavin
Mononucleotide
Tetrahydrobiopterin
Succinic acid
Succinic acid
Succinic acid
HIF1A
HIF1A
NFKB1
CPGDNA
ssRNA
dsDNA
Aerobic
Glycolysis
(Warburg
Effect)
Aerobic
Glycolysis
(Warburg
Effect)
Aerobic
Glycolysis
(Warburg
Effect)
Virus Cleared
Anti-
inflammatory
pathway
Tricarboxylic
acid cycle
FAD
Fe2+
Ascorbic acid
Heme
FAD
Inflammasome
Nucleus
Cell Division
Hypothalamus
Pituitary Gland
Adrenal Cortex
Liver
Blood Vessel
Macrophage
Blood Vessel
Dilation