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IRF3 IRF3 IRF3 TLR2 NFKB1 TLR4 IRF3 STAT1 IRF3 IFNAR1 IFNAR2 IFNB1 NOS2 TNF IL6 IL1B ACOD1 CRH ACOD1 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase EGLN2 HIF1A SLC2A1 IL1B TLR9 TICAM1 IRF3 MYD88 NFKB1 TLR3 MYD88 TICAM1 TLR7 MYD88 TICAM1 IRF7 NFKB1 IRF7 NFKB1 IRF7 HK2 IL1B IL1B IL1B IL6 IFNAR1 IFNAR2 IFNB1 TNF NOS2 Solute carrier family 2, facilitated glucose transporter member 2 Solute carrier family 22 member 5 Solute carrier family 13 member 3 Solute carrier family 2, facilitated glucose transporter member 1 Monocarboxylate transporter 4 Histone H4 Importin-4 IL1B Interleukin enhancer- binding factor 3 Exportin-5 Low affinity cationic amino acid transporter 2 Solute carrier family 22 member 8 Solute carrier family 22 member 2 Solute carrier family 22 member 2 Solute carrier family 22 member 8 Interleukin Transport IL6 IL1B TNF IFNAR1 IFNAR2 IFNB1 IL1B IL1B IL6 IL6 TNF TNF NOS2 PKM PKM PKM Tetrahydrobiopterin MYD88 TICAM2 IRF7 Flavin Mononucleotide Flavin Mononucleotide Tetrahydrobiopterin TICAM1 PKM Adrenocorticotropic hormone Adrenocorticotropic hormone Cortisol Epinephrine D-Glucose L-Lactic acid NO Citric acid L-Acetylcarnitine D-Glucose D-Glucose L-Acetylcarnitine L-Acetylcarnitine NO NO Succinic acid Succinic acid L-Lactic acid L-Arginine L-Arginine Cortisol Epinephrine Epinephrine Cortisol H+ NADPH O2 L-Arginine Citrulline NADP H2O Q FAD Fumaric acid QH2 FADH2 H+ NADPH O2 Citrulline NADP H2O NO L-Threonine L-Lysine L-Tryptophan L-Leucine L-Isoleucine L-Valine L-Arginine Glycine L-Serine Heme FAD 2Fe-2S Heme FAD Flavin Mononucleotide Tetrahydrobiopterin Succinic acid Succinic acid Succinic acid HIF1A HIF1A NFKB1 CPGDNA ssRNA dsDNA Aerobic Glycolysis (Warburg Effect) Aerobic Glycolysis (Warburg Effect) Aerobic Glycolysis (Warburg Effect) Virus Cleared Anti- inflammatory pathway Tricarboxylic acid cycle FAD Fe2+ Ascorbic acid Heme FAD Inflammasome Nucleus Cell Division Hypothalamus Pituitary Gland Adrenal Cortex Liver Blood Vessel Macrophage Blood Vessel Dilation