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Unknown Unknown Y+L amino acid transporter 1 4F2 cell-surface antigen heavy chain GTP cyclohydrolase GTP cyclohydrolase GTP cyclohydrolase GTP cyclohydrolase 6-pyruvoyl tetrahydrobiopterin synthase Sepiapterin reductase Sepiapterin reductase Aldose reductase Carbonyl reductase [NADPH] 1 Sepiapterin reductase Carbonyl reductase [NADPH] 1 Sepiapterin reductase Dihydrofolate reductase Sepiapterin reductase Phenylalanine- 4-hydroxylase Dihydropteridine reductase Guanosine triphosphate L-Phenylalanine L-Phenylalanine Formamidopyrimidine nucleoside triphosphate H2O 2,5-Diaminopyrimidine nucleoside triphosphate Formic acid H2O Formic acid 2,5-Diamino-6-(5'- triphosphoryl-3',4'- trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine Dihydroneopterin triphosphate H2O Dyspropterin PPPi NADP NADPH 1-hydroxy-2-Oxopropyl tetrahydropterin NADP 6-Lactoyltetrahydropterin NADPH NADP NADPH Sepiapterin NADPH 7,8-Dihydroneopterin NADP NADP NADPH NADP Tetrahydrobiopterin NADPH NADPH NADP H2O Neopterin NAD NADH O2 L-erythro-tetrahydrobiopterin L-Tyrosine Dihydrobiopterin NADPH NADP Zinc Zinc Zinc Zinc Zinc Fe2+ Purine Metabolism Cytosol Global development delay, microcephaly, and intellectual disability Dysphagia
Unknown Unknown SLC7A7 SLC3A2 GCH1 GCH1 GCH1 GCH1 PTS SPR SPR AKR1B1 CBR1 SPR CBR1 SPR DHFR SPR PAH QDPR Guanosine triphosphate L-Phenylalanine L-Phenylalanine Formamidopyrimidine nucleoside triphosphate Water 2,5- Diaminopyrimidine nucleoside triphosphate Formic acid Water Formic acid 2,5-Diamino- 6-(5'- triphosphoryl- 3',4'- trihydroxy- 2'- oxopentyl)- amino-4- oxopyrimidine Dihydroneopterin triphosphate Water Dyspropterin PPPi NADP NADPH 1-hydroxy-2- Oxopropyl tetrahydropterin NADP 6- Lactoyltetrahydropterin NADPH NADP NADPH Sepiapterin NADPH 7,8- Dihydroneopterin NADP NADP NADPH NADP Tetrahydrobiopterin NADPH NADPH NADP Water Neopterin NAD NADH Oxygen L-erythro- tetrahydrobiopterin L-Tyrosine Dihydrobiopterin NADPH NADP Purine Metabolism
SLC7A7 SLC3A2 GCH1 GCH1 GCH1 GCH1 PTS SPR SPR AKR1B1 CBR1 SPR CBR1 SPR DHFR SPR PAH QDPR GTP Phe Phe Formami H2O 25DNT Formate H2O Formate DTTOAO DHNTP H2O Dysprop PPPi NADP NADPH 1H2OT NADP 6-Lthpn NADPH NADP NADPH Sepiapt NADPH 7,8DHPN NADP NADP NADPH NADP BH4 NADPH NADPH NADP H2O Neopter NAD NADH O2 EryTbpn Tyr BH3 NADPH NADP Zinc Zinc Zinc Zinc Zinc Fe2+ PW000052 Cytosol Global development delay, microcephaly, and intellectual disability Dysphagia
SLC7A7 SLC3A2 GCH1 GCH1 GCH1 GCH1 PTS SPR SPR AKR1B1 CBR1 SPR CBR1 SPR DHFR SPR PAH QDPR GTP Phe Phe Formami H2O 25DNT Formate H2O Formate DTTOAO DHNTP H2O Dysprop PPPi NADP NADPH 1H2OT NADP 6-Lthpn NADPH NADP NADPH Sepiapt NADPH 7,8DHPN NADP NADP NADPH NADP BH4 NADPH NADPH NADP H2O Neopter NAD NADH O2 EryTbpn Tyr BH3 NADPH NADP PW000052