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Polymerase acidic protein Polymerase basic protein 2 Matrix protein 2 ABC transporter, substrate- binding lipoprotein RNA polymerase Hemagglutinin Neuraminidase Matrix protein 2 Nucleoprotein Non-structural protein 1 Nuclear export protein RNA-directed RNA polymerase catalytic subunit Polymerase basic protein 2 Polymerase acidic protein Polymerase basic protein 2 Polymerase acidic protein RNA polymerase Rimantadine Rimantadine Manganese Calcium Manganese Manganese Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Endocytosis Viral RNA Viral mRNA RNA replication Rimantadine inhibits matrix protein 2 on the influeza virus, which is responsible for the uncoating of the virus. The inhibition of matrix protein 2 prevents the virus from releasing viral RNA into the cell Translation Viral RNA and viral proteins are unable to be assembled or released due to the inhibition of viral uncoating Assembly Budding & Release Respiratory Epithelial Cell Cytosol Nucleus
Nucleus PA PB2 M CDR20291_0805 PB1 HA NA M NP NS NS PB1 PB2 PA PB2 PA PB1 Rimantadine Rimantadine Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA
PA PB2 M CDR20291_0805 PB1 HA NA M NP NS NS PB1 PB2 PA PB2 PA PB1 Rimanta Rimanta Mn2+ Ca2+ Mn2+ Mn2+ I A v A I A v A I A v A I A v A I A v A I A v A Endocytosis Viral RNA Viral mRNA RNA replication Rimantadine inhibits matrix protein 2 on the influeza virus, which is responsible for the uncoating of the virus. The inhibition of matrix protein 2 prevents the virus from releasing viral RNA into the cell Translation Viral RNA and viral proteins are unable to be assembled or released due to the inhibition of viral uncoating Assembly Budding & Release Respiratory Epithelial Cell Cytosol Nucleus
Nucleus PA PB2 M CDR20291_0805 PB1 HA NA M NP NS NS PB1 PB2 PA PB2 PA PB1 Rimanta Rimanta I A v A I A v A I A v A I A v A I A v A I A v A