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Polymerase acidic protein Polymerase basic protein 2 Polymerase basic protein 2 Polymerase acidic protein RNA polymerase Multidrug resistance- associated protein 4 Hemagglutinin Neuraminidase Matrix protein 2 Nucleoprotein Non-structural protein 1 Nuclear export protein RNA-directed RNA polymerase catalytic subunit Polymerase basic protein 2 Polymerase acidic protein ADP- ribosylation factor 6 RNA polymerase Favipiravir-RTP Favipiravir-RTP Favipiravir Favipiravir Pi Manganese Manganese Calcium Manganese Nucleoside diphosphate kinase A Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Magnesium Endocytosis Viral RNA Viral mRNA RNA replication Rimantadine inhibits matrix protein 2 on the influeza virus, which is responsible for the uncoating of the virus. The inhibition of the synthesis of mRNA prevents the translation of mRNA into required viral proteins Translation Viral RNA and viral proteins are unable to be assembled or released due to the inhibition of viral RNA polymerase Assembly Budding & Release Respiratory Epithelial Cell Cytosol Nucleus Favipiravir-RTP inhibits viral RNA polymerase which prevents RNA replication and synthesis of mRNA
PA PB2 PB2 PA PB1 ABCC4 HA NA M NP NS NS PB1 PB2 PA ARF6 PB1 Favipiravir-RTP Favipiravir-RTP Favipiravir Favipiravir Phosphate NME1 Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA
PA PB2 PB2 PA PB1 ABCC4 HA NA M NP NS NS PB1 PB2 PA ARF6 PB1 Fav-RTP Fav-RTP Favip Favip Pi Mn2+ Mn2+ Ca2+ Mn2+ NME1 I A v A I A v A I A v A I A v A I A v A I A v A Mg2+ Endocytosis Viral RNA Viral mRNA RNA replication Rimantadine inhibits matrix protein 2 on the influeza virus, which is responsible for the uncoating of the virus. The inhibition of the synthesis of mRNA prevents the translation of mRNA into required viral proteins Translation Viral RNA and viral proteins are unable to be assembled or released due to the inhibition of viral RNA polymerase Assembly Budding & Release Respiratory Epithelial Cell Cytosol Nucleus Favipiravir-RTP inhibits viral RNA polymerase which prevents RNA replication and synthesis of mRNA
PA PB2 PB2 PA PB1 ABCC4 HA NA M NP NS NS PB1 PB2 PA ARF6 PB1 Fav-RTP Fav-RTP Favip Favip Pi NME1 I A v A I A v A I A v A I A v A I A v A I A v A