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Pathway Description
Peramivir Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-05-16
Last Updated: 2023-10-25
Peramivir, also known as Rapivab, is an antiviral agent used to treat acute uncomplicated influenza A and B. Being a specific influenza virus neuraminidase inhibitor, peramivir works by preventing new viruses from emerging out of infected host cells. Viral Neuraminidase helps viruses to be released from the plasma membrane of the host cell after budding by cleaving terminal sialic acid residues from glycan structures on the surface of the infected cell. The active site of the neuraminidase enzyme is highly conserved, making it a good structure to inhibit. By inhibiting the NA catalytic site, peramivir causes viruses to aggregate and fail to be released from the cell surface. This drug has a low bioavailability when taken orally, so the only available formulation is the injectable intravenous.
References
Peramivir Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Bantia S, Arnold CS, Parker CD, Upshaw R, Chand P: Anti-influenza virus activity of peramivir in mice with single intramuscular injection. Antiviral Res. 2006 Jan;69(1):39-45. doi: 10.1016/j.antiviral.2005.10.002. Epub 2005 Nov 21.
Pubmed: 16325932
Kodama M, Yoshida R, Hasegawa T, Izawa M, Kitano M, Baba K, Noshi T, Seki T, Okazaki K, Tsuji M, Kanazu T, Kamimori H, Homma T, Kobayashi M, Sakoda Y, Kida H, Sato A, Yamano Y: The relationship between in vivo antiviral activity and pharmacokinetic parameters of peramivir in influenza virus infection model in mice. Antiviral Res. 2014 Sep;109:110-5. doi: 10.1016/j.antiviral.2014.06.016. Epub 2014 Jul 2.
Pubmed: 24997412
Alame MM, Massaad E, Zaraket H: Peramivir: A Novel Intravenous Neuraminidase Inhibitor for Treatment of Acute Influenza Infections. Front Microbiol. 2016 Mar 31;7:450. doi: 10.3389/fmicb.2016.00450. eCollection 2016.
Pubmed: 27065996
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