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Pathway Description
Gliquidone Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-05-26
Last Updated: 2023-10-25
Gliquidone is an anti-diabetic sulfonylurea drug used in the management of diabetes mellitus type 2. In patients with diabetes mellitus, there is a deficiency or absence of insulin. The mechanism of action of gliquidone in lowering blood glucose is by stimulating the release of insulin from pancreatic beta cells, and increasing the sensitivity of peripheral tissues to insulin. Gliquidone binds and inhibits the ATP-sensitive potassium channel receptors ( ATP-binding cassette sub-family C member 8) on the pancreatic cell surface, reducing potassium conductance and causing the depolarization of the membrane. In consequence, the depolarization stimulates the calcium ion influx through voltage-sensitive calcium channels. This action increases the intracellular calcium ion concentration and then induces the secretion of insulin (by exocytosis). The ATP-sensitive potassium channel is a hetero-octameric protein. This channel has 2 different subunits. This drug, gliquidone inhibits both the sulfonylurea receptor (SUR) and the second one which is the inwardly rectifying K+ channel (kir6.x). This last interaction is very weak. Gliquidone is administered as an oral tablet.
References
Gliquidone Pathway References
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Pubmed: 16641997
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