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NFKB1
Glucocorticoid
receptor
Transcription
factor AP-1
Glucocorticoid
receptor
Prostaglandin
G/H synthase 2
Annexin A1
Cytosolic
phospholipase
A2
Annexin A1
ATP-binding
cassette
sub-family A
member 1
Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Thromboxane-A
synthase
Prostacyclin
synthase
Prostaglandin E
synthase
Prostaglandin-
H2 D-isomerase
Aldo-keto
reductase
family 1 member
C3
Aldo-keto
reductase
family 1 member
C3
Carbonyl
reductase
[NADPH] 1
11-beta-
hydroxysteroid
dehydrogenase 1
Glucocorticoid
receptor
Glucocorticoid
receptor
Glucocorticoid
receptor
Heat shock
protein HSP
90-alpha
Heat shock 70
kDa protein
1A/1B
Peptidyl-prolyl
cis-trans
isomerase FKBP4
Peptidyl-prolyl
cis-trans
isomerase FKBP4
Heat shock
protein HSP
90-alpha
Heat shock 70
kDa protein
1A/1B
Arachidonic acid
Cortisone acetate
Cortisone acetate
Cortisol
Cortisol
Cortisol
O
2
Prostaglandin G2
Prostaglandin H2
H
2
O
Thromboxane A2
Prostaglandin I2
Prostaglandin E2
Prostaglandin D2
NADPH
11-Epi-PGF2a
NADP
Prostaglandin F2a
NADPH
NADP
PC(18:0/20:4(5Z,8Z,11Z,14Z))
H
2
O
LysoPC(18:0/0:0)
Cortisol
1-Methylhistidine
Heme
Heme
Glutathione
NADPH
Cortisol
Cortisol
Acceptor
Reduced
acceptor
Activator
Protein 1
NF-kB
C/EBP
Prostaglandin Synthase G/H 2
Promoter
Annexin-1
Linoleic Acid
Metabolism
Eicosanoids
Calcium
Heme
Heme
Heme
Heme
Glucocorticoid
receptor-cortisol complex
binds to the promoter for
Annexin-1 (A1) and
upregulates the
transcription of it.
Glucocorticoid
receptor-cortisol complex
inhibits transcription
factors NF-kB and Activator
Protein 1 (AP-1) from
synthesizing prostaglandin
G/H synthase 2 (COX-2).
Lower concentrations of
prostaglanding I2 reduces
vasodilation so the swelling
of inflammation decreases.
Prostaglandin I2 is apart of
the hyperalgesia response so
it's decrease results in a
reduced pain sensitivity.
Lower concentrations of
prostaglandin D2 decreases
the activity of platelet
aggregation as well as
reducing vasodilation
Nucleus
Lower concentrations of
prostaglandin E2 have
similar effects fo PGI2 as
it's reduction decreases
vasodilation and pain
sensitivity.
Lower concentrations of
prostagladin F2a decreases
the amount of
bronchoconstriction allowing
air to flow more easily.
Cortisol (also called
Hydrocortisone) readily
crosses the cell membrane
since they are highly
lipophillic.
Cytoplasm
Phospholipase A2 is
inhibited by Annexin-1 as it
binds to the Ca2+ which is
needed by phospholipase A2
to function. This inhibition
reduces the amount of
arachidonic acid that is
cleaved from phospholipids.
Lower concentrations of
prostaglandin G/H synthase 2
result in the synthesis of
prostaglandin G2 and H2 to
be reduced. The reduction
lowers the amount of
prostanoids being produced
which have varying effects
on decreasing inflammation
and immune response.
As cortisol binds to the
glucocorticoid receptor, the
chaperone proteins fall off.
Glucocorticoid
receptor-cortisol complex
translocates into the
nucleus.
Thromboxane A2 is
responsible for activation
of new platelets as well as
platelet aggravation.
Decreased levels of
thromboxane A2 will decrease
levels of platelet activity.
Endoplasmic Reticulum
Prostaglandin G/H Synthase 2
exits the nucleus through
nuclear pores into the cell
cytosol.
Liver
Human Cell
Blood vessel
Endoplasmic Reticulum
Nucleus
NFKB1
Unknown
JUN
Unknown
PTGS2
ANXA1
PLA2G4A
ANXA1
ABCA1
PTGS1
PTGS2
PTGS1
PTGS2
TBXAS1
PTGIS
PTGES
PTGDS
AKR1C3
AKR1C3
CBR1
HSD11B1
Unknown
Unknown
Unknown
HSP90AA1
HSPA1A
FKBP4
FKBP4
HSP90AA1
HSPA1A
Arachidonic
acid
Cortisone
acetate
Cortisone
acetate
Cortisol
Cortisol
Cortisol
Oxygen
Prostaglandin
G2
Prostaglandin
H2
Water
Thromboxane A2
Prostaglandin
I2
Prostaglandin
E2
Prostaglandin
D2
NADPH
11-Epi-PGF2a
NADP
Prostaglandin
F2a
NADPH
NADP
PC(18:0/20:4(5Z,8Z,11Z,14Z))
Water
LysoPC(18:0/0:0)
Cortisol
1-
Methylhistidine
Cortisol
Cortisol
Acceptor
Reduced
acceptor
Activator
Protein 1
NF-kB
C/EBP
Prostaglandin
Synthase G/H
2
Promoter
Annexin-1