Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loader

Loading Pathway...

Ibalizumab C-C chemokine receptor type 5 Integrase Reverse transcriptase/RNaseH Gag-Pol polyprotein Integrase HIV-1 protease Reverse transcriptase protein HIV-1 protease Integrase Reverse transcriptase/RNaseH Gag-Pol polyprotein Integrase HIV-1 protease Reverse transcriptase protein HIV-1 protease Envelope glycoprotein gp160 Transmembrane protein gp41 Surface protein gp120 T-cell surface glycoprotein CD4 Surface protein gp120 T-cell surface glycoprotein CD4 HIV-1 DNA HIV-1 DNA HIV-1 DNA DNA Single strand RNA HIV-1 DNA DNA Single strand RNA Integration Magnesium Magnesium HIV Infected T-Cell Nucleus Viral RNA Viral DNA Viral DNA is integrated into the host DNA Transcription Viral mRNA Cytosol The virus is unable to enter the cell since the gp-120-CD4 complex is not able to interact with CCR5 or CXCR4. Due to the inhibition of entry and fusion to the host cell, new viruses do not form and release. HIV-1 protease normally cleaves the Gag-pol polyprotein into 66 molecular species, including HIV-1 protease, integrase, and reverse transcriptase. Ibalizumab inhibits the T-cell surface glycoprotein CD4 by binding to the domain 2. This drug blocks the gp-120-CD4 complex from interacting with CCR5 or CXCR4 and thus prevents entry and fusion of HIV. T-Cell Blood Vessel HIV Infected T-Cell Nucleus Viral RNA Viral DNA Viral DNA is integrated into the host DNA Transcription Translation Viral mRNA Cytosol The virus is unable to enter the cell since the gp-120-CD4 complex is not able to interact with CCR5 or CXCR4. Due to the inhibition of entry and fusion to the host cell, new viruses do not form and release. Viral DNA is transcribed into viral mRNA HIV-1 protease normally cleaves the Gag-pol polyprotein into 66 molecular species, including HIV-1 protease, integrase, and reverse transcriptase. T-Cell
Melanosome Nucleus Unknown CCR5 pol pol gag-pol pol HIV-1 protease reverse transcriptase HIV-1 protease pol pol gag-pol pol HIV-1 protease reverse transcriptase HIV-1 protease env env env CD4 env CD4 HIV-1 DNA HIV-1 DNA HIV-1 DNA DNA Single strand RNA HIV-1 DNA DNA Single strand RNA
CCR5 pol pol gag-pol pol HIV-1 protease reverse transcriptase HIV-1 protease pol pol gag-pol pol HIV-1 protease reverse transcriptase HIV-1 protease env env env CD4 env CD4 HI-1 DN HI-1 DN HI-1 DN DNA ssRNA HI-1 DN DNA ssRNA Integration Mg2+ Mg2+ HIV Infected T-Cell Nucleus Viral RNA Viral DNA Viral DNA is integrated into the host DNA Transcription Viral mRNA Cytosol The virus is unable to enter the cell since the gp-120-CD4 complex is not able to interact with CCR5 or CXCR4. Due to the inhibition of entry and fusion to the host cell, new viruses do not form and release. HIV-1 protease normally cleaves the Gag-pol polyprotein into 66 molecular species, including HIV-1 protease, integrase, and reverse transcriptase. Ibalizumab inhibits the T-cell surface glycoprotein CD4 by binding to the domain 2. This drug blocks the gp-120-CD4 complex from interacting with CCR5 or CXCR4 and thus prevents entry and fusion of HIV. T-Cell Blood Vessel HIV Infected T-Cell Nucleus Viral RNA Viral DNA Viral DNA is integrated into the host DNA Transcription Translation Viral mRNA Cytosol The virus is unable to enter the cell since the gp-120-CD4 complex is not able to interact with CCR5 or CXCR4. Due to the inhibition of entry and fusion to the host cell, new viruses do not form and release. Viral DNA is transcribed into viral mRNA HIV-1 protease normally cleaves the Gag-pol polyprotein into 66 molecular species, including HIV-1 protease, integrase, and reverse transcriptase. T-Cell
Melanosome Nucleus CCR5 pol pol gag-pol pol HIV-1 protease reverse transcriptase HIV-1 protease pol pol gag-pol pol HIV-1 protease reverse transcriptase HIV-1 protease env env env CD4 env CD4 HI-1 DN HI-1 DN HI-1 DN DNA ssRNA HI-1 DN DNA ssRNA