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P2X purinoceptor 4 Glutamate receptor 1 Glutamate receptor 2 Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-3 Glutamate [NMDA] receptor subunit epsilon-2 Glutamate [NMDA] receptor subunit epsilon-4 Glutamate [NMDA] receptor subunit 3A Glutamate [NMDA] receptor subunit 3B Multidrug resistance- associated protein 4 Solute carrier family 22 member 11 Potassium voltage-gated channel subfamily D member 2 Kv channel- interacting protein 2 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Cytochrome P450 3A4 Eslicarbazepine Glutamate Eslicarbazepine Eslicarbazepine Na+ Na+ K+ K+ Ca+ Ca+ Glutamate Na+ Na+ Ca+ Ca+ Ca+ Ca+ Eslicarbazepine Acetate Eslicarbazepine Acetate Eslicarbazepine Acetate Heme Depolarization axon width = 9 Eslicarbazepine blocks the channel, preventing the entry of sodium into the neuron. Endoplasmic Reticulum Hepatocyte Eslicarbazepine acetate is converted to Eslicarbazepine which is responsible for the pharmacological action. axon width = 9 Presynaptic Neuron Post-synaptic Neuron Since no action potential arrives to the nerve terminal, calcium entry does not occur and neurotransmitters like glutamate are not released from synaptic vesicles into the synapse. Membrane Potential (mV) 0 40 -70 Hyperpolarization Repolarization Peak action potential Resting potential The depolarization phase of the action potential is inhibited, therefore, the action potential cannot be geenrated. ACTION POTENTIAL Time (ms) The post-synaptic neuron is unable to depolarize due to the inhibition of neurotransmitter release. Synaptic Vesicle Eslicarbazepine acetate is administered as an oral tablet.
Endoplasmic Reticulum Vacuole Mitochondria P2RX4 GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B ABCC4 SLC22A11 KCND2 KCNIP2 CACNA1A CACNB1 CACNA2D2 CACNA1H CACNA1G CYP3A4 Eslicarbazepine Glutamate Eslicarbazepine Eslicarbazepine Sodium Sodium Potassium Potassium Calcium Calcium Glutamate Sodium Sodium Calcium Calcium Calcium Calcium Eslicarbazepine Acetate Eslicarbazepine Acetate Eslicarbazepine Acetate
P2RX4 GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B ABCC4 SLC22A11 KCND2 KCNIP2 CACNA1A CACNB1 CACNA2D2 CACNA1H CACNA1G CYP3A4 Eslic Gluta Eslic Eslic Na+ Na+ K+ K+ Ca+ Ca+ Gluta Na+ Na+ Ca+ Ca+ Ca+ Ca+ Esl Ace Esl Ace Esl Ace Heme Depolarization axon width = 9 Eslicarbazepine blocks the channel, preventing the entry of sodium into the neuron. Endoplasmic Reticulum Hepatocyte Eslicarbazepine acetate is converted to Eslicarbazepine which is responsible for the pharmacological action. axon width = 9 Presynaptic Neuron Post-synaptic Neuron Since no action potential arrives to the nerve terminal, calcium entry does not occur and neurotransmitters like glutamate are not released from synaptic vesicles into the synapse. Membrane Potential (mV) 0 40 -70 Hyperpolarization Repolarization Peak action potential Resting potential The depolarization phase of the action potential is inhibited, therefore, the action potential cannot be geenrated. ACTION POTENTIAL Time (ms) The post-synaptic neuron is unable to depolarize due to the inhibition of neurotransmitter release. Synaptic Vesicle Eslicarbazepine acetate is administered as an oral tablet.
Endoplasmic Reticulum Vacuole Mitochondria P2RX4 GRIA1 GRIA2 GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIN3A GRIN3B ABCC4 SLC22A11 KCND2 KCNIP2 CACNA1A CACNB1 CACNA2D2 CACNA1H CACNA1G CYP3A4 Eslic Gluta Eslic Eslic Na+ Na+ K+ K+ Ca2+ Ca2+ Gluta Na+ Na+ Ca2+ Ca2+ Ca2+ Ca2+ Esl Ace Esl Ace Esl Ace