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Myosin light chain kinase, smooth muscle Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Myosin LC-P Myosin light chain 3 Inositol 1,4,5- trisphosphate receptor type 1 Myosin light chain phosphatase Calmodulin Calmodulin Voltage- dependent calcium channel subunit alpha-2/delta-1 Manidipine Ca+ Ca+ Ca+ Ca+ Manidipine Ca+ Muscle Contraction Muscle Relaxation G Protein Signalling Cascade Magnesium Calcium Manganese Sarcoplasmic Reticulum Cytosol Vascular Smooth Muscle Cell Manidipine binds and inhibits both L type and T type calcium channels preventing calcium influx Activation or inhibition of the receptors linked to the G protein signalling cascade can alter calcium levels in the cell. There is an overall decrease in calcium levels in the cytosol. Decreased calcium is unable to bind readily to calmodulin. The inhibition of myosin light chain kinase prevents the synthesis of Myosin LC-P which leads to a high concentration of myosin light chain and muscle relaxation. Myosin unbinds from actin causing the sarcomere filaments to slide leading to muscle relaxation. Relaxation Actin Myosin Manidipine is administered as an oral tablet
MYLK CACNB1 CACNA1C CACNA1H CACNA1G MYL3 MYL3 ITPR1 PPP1CB CALM1 CALM1 CACNA2D1 Manidipine Calcium Calcium Calcium Calcium Manidipine Calcium Muscle Contraction Muscle Relaxation G Protein Signalling Cascade
MYLK CACNB1 CACNA1C CACNA1H CACNA1G MYL3 MYL3 ITPR1 PPP1CB CALM1 CALM1 CACNA2D1 Manid Ca+ Ca+ Ca+ Ca+ Manid Ca+ Mus Con Mus Rel G P S C Mg2+ Ca2+ Mn2+ Sarcoplasmic Reticulum Cytosol Vascular Smooth Muscle Cell Manidipine binds and inhibits both L type and T type calcium channels preventing calcium influx Activation or inhibition of the receptors linked to the G protein signalling cascade can alter calcium levels in the cell. There is an overall decrease in calcium levels in the cytosol. Decreased calcium is unable to bind readily to calmodulin. The inhibition of myosin light chain kinase prevents the synthesis of Myosin LC-P which leads to a high concentration of myosin light chain and muscle relaxation. Myosin unbinds from actin causing the sarcomere filaments to slide leading to muscle relaxation. Relaxation Actin Myosin Manidipine is administered as an oral tablet
MYLK CACNB1 CACNA1C CACNA1H CACNA1G MYL3 MYL3 ITPR1 PPP1CB CALM1 CALM1 CACNA2D1 Manid Ca2+ Ca2+ Ca2+ Ca2+ Manid Ca2+ Mus Con Mus Rel G P S C