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Pathway Description
Solriamfetol Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-06-21
Last Updated: 2023-11-27
Solriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI). This drug is indicated for the daytime treatment of sleepiness associated with narcolepsy or obstructive sleep apnea. Solriamfetol was given FDA approval in 2019. Solriamfetol weakly binds to dopamine and norepinephrine transporters but not serotonin transporters. Those transporters are called sodium-dependent dopamine transporter and sodium-dependent noradrenaline transporter. This makes more dopamine and noradrenaline available in the synapses of the brain. In consequence, the postsynaptic has more of those neurotransmitters available. Norepinephrine and dopamine are important neurotransmitters in sleep-wake regulation. This drug is available as oral tablets.
References
Solriamfetol Pathway References
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