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Pathway Description
Benzthiazide Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-06-22
Last Updated: 2023-11-27
Benzthiazide is a diuretic that acts by promoting water loss from the body. This drug is used in the treatment of hypertension and edema. They act on the kidneys by inhibiting the sodium-chloride reabsorption (via the Na+/Cl- cotransporter) from its early distal tubules. This inhibition of the cotransporter results in the increased excretion of sodium, chloride, and, in consequence, water. At the same time, it inhibits sodium transport across the renal tubular epithelium (by binding the Na+/Cl- cotransporter). In consequence, this will increase potassium excretion via the sodium-potassium exchange mechanism. The exact name of the inhibited transporter is the solute carrier family 12 member 3. The antihypertensive function of the drug is not well defined, but it is thought to act by the drug inhibition on the carbonic anhydrase or on the large-conductance calcium-activated potassium (kCa) channel, in the smooth muscles. An overdose of benzthiazide would result in symptoms like nausea, vomiting, drowsiness, and urinary problems. This drug is administered as an oral tablet.
References
Benzthiazide Pathway References
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Pubmed: 8041726
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Pubmed: 2430951
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Pubmed: 7536695
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Pubmed: 12953268
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Pubmed: 15174025
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