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Pathway Description
Desirudin Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-07-05
Last Updated: 2023-11-27
Desirudin is an inhibitor of thrombin, similar in structure to hirudin a naturally occurring anticoagulant peptide produced by salivary glands in leeches. This drug is administered to prevent deep vein thrombosis, some possible side effects include bleeding gums, blood collecting under the skin, coughing up blood, bruising and difficulty breathing and or swallowing. Desirudin binds to the active site of thrombin inhibiting the conversion of fibrinogen to fibrin, due to this stopping the formation of a blood clot. This is usually administered subcutaneously, it is then metabolized and eliminated via the kidney. Due to the anticoagulant properties herbs and supplements with anticoagulant and antiplatelet activity should be avoided, this includes ginger, garlic, bilberry, danshen, piracetam and ginkgo biloba.
References
Desirudin Pathway References
Van Hecken, A., Depré, M., Verbesselt, R., Arnout, J., De Lepeleire, I., Laethem, T., Navarro, V., Campanile, A., Vega, J., & De Hoon, J. (2002). Desirudin: effect on blood coagulation tests in vitro and following a subcutaneous administration in healthy volunteers. British Journal of Clinical Pharmacology, 54(5), 563. https://doi.org/10.1046/j.1365-2125.2002.t01-6-01714.x
Matheson, A.J., Goa, K.L. Desirudin. Drugs 60, 679–700 (2000). https://doi.org/10.2165/00003495-200060030-00012
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Pubmed: 1482812
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Pubmed: 14702039
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Pubmed: 2318848
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Pubmed: 3030813
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Pubmed: 14574404
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Pubmed: 6959130
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Pubmed: 6687940
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Pubmed: 6329734
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Pubmed: 3935400
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Pubmed: 6438526
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Pubmed: 1427887
Jenny RJ, Pittman DD, Toole JJ, Kriz RW, Aldape RA, Hewick RM, Kaufman RJ, Mann KG: Complete cDNA and derived amino acid sequence of human factor V. Proc Natl Acad Sci U S A. 1987 Jul;84(14):4846-50. doi: 10.1073/pnas.84.14.4846.
Pubmed: 3110773
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Pubmed: 1567832
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. doi: 10.1038/nature04727.
Pubmed: 16710414
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