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5-
hydroxytryptamine
receptor 2A
5-
hydroxytryptamine
receptor 2B
5-
hydroxytryptamine
receptor 2C
Synaptic
vesicular amine
transporter
Sodium-
dependent
serotonin
transporter
Solute carrier
organic anion
transporter
family member
2B1
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Serotonin
Fluoxetine
Serotonin
Serotonin
Serotonin
Na
+
Na
+
Fluoxetine
Fluoxetine
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
Fe2+
Increase in
vagus nerve
stimulation and
electrical
impulses
suppression of
depression and
anxiety
Pyridoxal
5'-phosphate
The serotonin receptors
2A,B,C are responsible for a
variety of cognitive
abilities such as learning,
appetite, anxiety, memory,
mood and sleep.
Fluoxetine is rapidly
absorbed from the
gastrointestinal tract.
Presynaptic neuron
Cytosol
Synaptic Vesicle
Postsynaptic Neuron
Cytosol
Synapse
Fluoxetine inhibits the
serotonin reuptake
transporter, causing
serotonin accumulation in
the synaptic cleft
Increasing activation of
serotonin receptors can
increase stimulus for
changes in downstream
effects of these receptors
affecting the mental state
of the individual
Brain
Raphei nuclei located in the
midline of the brain stem
Norfluoxetine is an active
metabolite of fluoxetine
HTR2A
HTR2B
HTR2C
SLC18A2
SLC6A4
SLCO2B1
TPH1
DDC
Serotonin
Fluoxetine
Serotonin
Serotonin
Serotonin
Sodium
Sodium
Fluoxetine
Fluoxetine
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Increase in
vagus nerve
stimulation and
electrical
impulses
suppression of
depression and
anxiety
HTR2A
HTR2B
HTR2C
SLC18A2
SLC6A4
SLCO2B1
TPH1
DDC
5-HT
Fluox