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Coagulation factor VII Tissue factor Coagulation factor XIa Coagulation factor IX Prothrombin Coagulation factor VIII Coagulation factor V Coagulation factor IX Coagulation factor X Coagulation factor X Prothrombin Thrombin Fibrinogen Coagulation factor XIIIa Fibrin (loose) Fibrin (mesh) Fibrin (mesh) Fibrin (mesh) Fibrin degradation products Fibrin degradation products Fibrin degradation products Plasminogen Coagulation factor X Coagulation factor XIII Thrombin Coagulation factor VIII Coagulation factor V Coagulation factor VIIa Tissue factor Argatroban Calcium Calcium Calcium Calcium Calcium Calcium Calcium Calcium Calcium Tenase Complex Prothrombinase Complex Extrinsic Pathway Vascular Injury At the site of injury collagen and tissue factor are exposed to coagulation factors in the blood activating the extrinsic pathway. Extracellular Space The fibrin mesh/clot forms at the site of vascular injury, blocking the leaking blood. Blood Vessel Argatroban binds and inhibits thrombin, stopping conversion of fibrinogen to fibrin. Overall halting the clotting cascade, preventing the formation of clots Argatroban is administered intravenously, it then diffuses into the bloodstream
Melanosome F7 Unknown Unknown F9 Unknown F8 F5 F9 F10 F10 Unknown Unknown Unknown F13A1 Unknown Unknown Unknown FGG Unknown Unknown FGG PLG F10 Unknown Unknown F8 F5 F7 Unknown Argatroban
F7 F9 F8 F5 F9 F10 F10 F13A1 FGG FGG PLG F10 F8 F5 F7 Argatro Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Tenase Complex Prothrombinase Complex Extrinsic Pathway Vascular Injury At the site of injury collagen and tissue factor are exposed to coagulation factors in the blood activating the extrinsic pathway. Extracellular Space The fibrin mesh/clot forms at the site of vascular injury, blocking the leaking blood. Blood Vessel Argatroban binds and inhibits thrombin, stopping conversion of fibrinogen to fibrin. Overall halting the clotting cascade, preventing the formation of clots Argatroban is administered intravenously, it then diffuses into the bloodstream
Melanosome F7 F9 F8 F5 F9 F10 F10 F13A1 FGG FGG PLG F10 F8 F5 F7 Argatro