Toggle navigation
PathBank
Browse
Pathways
Table of Primary Pathways
Compounds
Proteins
Search
Advanced Text Search
ChemQuery Structure Search
Molecular Weight Search
Sequence Search
Analyze
Over-Representation Analysis
Path-MAP Analysis
Pathway Enrichment Analysis
About
About PathBank
Statistics
Style Guide
Other Databases
Pathway Legend
Pathway Category Definitions
PathWhiz
Downloads
Contact Us
Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loading Pathway...
Error: Pathway image not found.
D(2) dopamine
receptor
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Sodium-
dependent
dopamine
transporter
Synaptic
vesicular amine
transporter
Solute carrier
family 22
member 1
Aromatic-L-
amino-acid
decarboxylase
Tyrosine
3-monooxygenase
Guanine
nucleotide-
binding protein
G(s) subunit
alpha isoforms
short
Dopamine
Ca
+
Ziprasidone
Ca
+
Dopamine
Dopamine
Ziprasidone
Ziprasidone
L-Dopa
CO
2
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
Na
+
Na
+
Pyridoxal
5'-phosphate
GDP
Gi signaling
cascade
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Ziprasidone is a D2 receptor
antagonist. D2 receptors in
the mesolimbic pathway are
responsible for producing
the positive symptoms in
schizophrenia
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Excess dopamine in the brain
triggers positive symptoms
of schizophrenia
Brain
Mesolimbic pathway
Blood vessel - blood brain
barrier
Ziprasidone is taken orally
and absorbed from the
gastrointestinal tract
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
SLC22A1
DDC
TH
GNAS
Dopamine
Calcium
Ziprasidone
Calcium
Dopamine
Dopamine
Ziprasidone
Ziprasidone
L-Dopa
Carbon dioxide
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
Sodium
Sodium
Guanosine
diphosphate
Gi signaling
cascade
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
SLC22A1
DDC
TH
GNAS
LDP
Ca
+
Ziprasi
Ca
+
LDP
LDP
Ziprasi
Ziprasi
L-Dopa
CO
2
Tyr
BH4
O
2
BH3
H
2
O
Na
+
Na
+
Pyr-5'P
GDP
Gi si c
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Ziprasidone is a D2 receptor
antagonist. D2 receptors in
the mesolimbic pathway are
responsible for producing
the positive symptoms in
schizophrenia
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Excess dopamine in the brain
triggers positive symptoms
of schizophrenia
Brain
Mesolimbic pathway
Blood vessel - blood brain
barrier
Ziprasidone is taken orally
and absorbed from the
gastrointestinal tract