Quantitative metabolomics services for biomarker discovery and validation.
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5- hydroxytryptamine receptor 2A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Solute carrier family 12 member 3 Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Thiethylperazine Ca+ Serotonin Thiethylperazine Thiethylperazine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ psychotic effects Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Thiethylperazine also acts as an antagonist to 5HT2C, Dopamine 1,2,4 receptor types, M1- M5, alpha (1) and H1 receptors Thiethylperazine is taken orally and absorbed from the gastrointestinal tract
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 SLC12A3 TPH1 DDC Calcium Serotonin Serotonin Thiethylperazine Calcium Serotonin Thiethylperazine Thiethylperazine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Gq signaling cascade
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 SLC12A3 TPH1 DDC Ca+ 5-HT 5-HT Tietilp Ca+ 5-HT Tietilp Tietilp Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Fe2+ Pyr-5'P Gq si c Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ psychotic effects Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Thiethylperazine also acts as an antagonist to 5HT2C, Dopamine 1,2,4 receptor types, M1- M5, alpha (1) and H1 receptors Thiethylperazine is taken orally and absorbed from the gastrointestinal tract