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D(2) dopamine
receptor
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Sodium-
dependent
dopamine
transporter
Synaptic
vesicular amine
transporter
Aromatic-L-
amino-acid
decarboxylase
Tyrosine
3-monooxygenase
Guanine
nucleotide-
binding protein
G(s) subunit
alpha isoforms
short
Dopamine
Ca
+
Sulpiride
Ca
+
Dopamine
Dopamine
Sulpiride
L-Dopa
CO
2
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
Na
+
Na
+
Pyridoxal
5'-phosphate
GDP
Gi signaling
cascade
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Sulpiride is a D2 receptor
antagonist. D2 receptors in
the mesolimbic pathway are
responsible for producing
the positive symptoms in
schizophrenia
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Excess dopamine in the brain
triggers positive symptoms
of schizophrenia
Brain
Mesolimbic pathway
Blood vessel - blood brain
barrier
Sulpiride is taken orally
and absorbed from the
gastrointestinal tract
passive diffusion
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
GNAS
Dopamine
Calcium
Sulpiride
Calcium
Dopamine
Dopamine
Sulpiride
L-Dopa
Carbon dioxide
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
Sodium
Sodium
Guanosine
diphosphate
Gi signaling
cascade
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
GNAS
LDP
Ca
+
Sulpiri
Ca
+
LDP
LDP
Sulpiri
L-Dopa
CO
2
Tyr
BH4
O
2
BH3
H
2
O
Na
+
Na
+
Pyr-5'P
GDP
Gi si c
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Sulpiride is a D2 receptor
antagonist. D2 receptors in
the mesolimbic pathway are
responsible for producing
the positive symptoms in
schizophrenia
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Excess dopamine in the brain
triggers positive symptoms
of schizophrenia
Brain
Mesolimbic pathway
Blood vessel - blood brain
barrier
Sulpiride is taken orally
and absorbed from the
gastrointestinal tract
passive diffusion