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5-
hydroxytryptamine
receptor 6
5-
hydroxytryptamine
receptor 7
Sodium-
dependent
serotonin
transporter
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Synaptic
vesicular amine
transporter
Unknown
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Ca
+
Serotonin
Serotonin
Amoxapine
Ca
+
Serotonin
Amoxapine
Na
+
Na
+
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
Fe2+
Pyridoxal
5'-phosphate
Modulate cyclic
adenosine
triphosphate
Regulation of
Fyn kinase
Induction of
structural
plasticity
cAMP
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ Negative symptoms of
schizophrenia
Serotonin is synthesized and
stored in synaptic vesicles
at the nerve terminal
Amoxapine is a weak partial
agonist at 5HT 6 and 7
receptors where it acts as a
functional antagonist to
reduce negative symptoms of
schizophrenia
↑Cognitive Improvement
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
passive diffusion
Suppression of depression
and anxiety
Serotonin helps with
learning, memory, happiness,
body temperature, sleep,
sexual behaviour, and
hunger, which helps supress
depression and anxiety
HTR6
HTR7
SLC6A4
CACNA1A
CACNB1
CACNA2D2
SLC18A2
Unknown
TPH1
DDC
Calcium
Serotonin
Serotonin
Amoxapine
Calcium
Serotonin
Amoxapine
Sodium
Sodium
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Modulate cyclic
adenosine
triphosphate
Regulation of
Fyn kinase
Induction of
structural
plasticity
cAMP
HTR6
HTR7
SLC6A4
CACNA1A
CACNB1
CACNA2D2
SLC18A2
TPH1