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Adenylate Cyclase Plasma membrane Ca-ADPase G protein complex Prostacyclin receptor Solute carrier organic anion transporter family member 1B1 Liver carboxylesterase 1 cAMP ADP Metabolite ACT-333679 Ca+ Ca+ Selexipag Selexipag Selexipag Metabolite ACT-333679 Magnesium cAMP Metabolite ACT 333679 acts as an agonist and binds to prostacyclin receptor Due to elevated levels of cAMP the pathways needed for platelet activation and aggregation are inhibited. Such as calcium, which is effluxes from the cell stopping aggregation Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Blood Vessel or Cell Damage Selexipag is administered orally and through first pass metabolism is broken down into its active metabolite Blood Vessel Hepatocyte Endoplasmic Reticulum Selexipag is a prodrug, meaning that it has to be metabolized into its active form in order to act on its targets. Selexipag is converted by liver carboxylesterase 1 into its active metabolite ACT 333679
Melanosome Chloroplast Chloroplast Endoplasmic Reticulum ADCY10 Unknown GNG2 PTGIR SLCO1B1 CES1 cAMP Adenosine diphosphate Metabolite ACT-333679 Calcium Calcium Selexipag Selexipag Selexipag Metabolite ACT-333679
ADCY10 GNG2 PTGIR SLCO1B1 CES1 cAMP ADP Me AC-3 Ca+ Ca+ Selex Selex Selex Me AC-3 Mg2+ cAMP Metabolite ACT 333679 acts as an agonist and binds to prostacyclin receptor Due to elevated levels of cAMP the pathways needed for platelet activation and aggregation are inhibited. Such as calcium, which is effluxes from the cell stopping aggregation Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Blood Vessel or Cell Damage Selexipag is administered orally and through first pass metabolism is broken down into its active metabolite Blood Vessel Hepatocyte Endoplasmic Reticulum Selexipag is a prodrug, meaning that it has to be metabolized into its active form in order to act on its targets. Selexipag is converted by liver carboxylesterase 1 into its active metabolite ACT 333679
Melanosome Chloroplast Chloroplast Endoplasmic Reticulum ADCY10 GNG2 PTGIR SLCO1B1 CES1 cAMP ADP Me AC-3 Ca2+ Ca2+ Selex Selex Selex Me AC-3