Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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5- hydroxytryptamine receptor 2A 5- hydroxytryptamine receptor 7 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Amisulpride Amisulpride Ca+ Serotonin Amisulpride Amisulpride Amisulpride L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade GPCR signaling pathway Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ Negative symptoms of schizophrenia Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Amisulpride binds to 5HT2A and 5HT7 receptors where it acts as a functional antagonist to reduce negative symptoms of schizophrenia ↑Cognitive Improvement Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Passive Diffusion Antidepressant effects passive diffusion
HTR2A HTR7 CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Amisulpride Amisulpride Calcium Serotonin Amisulpride Amisulpride Amisulpride L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Gq signaling cascade GPCR signaling pathway
HTR2A HTR7 CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca+ 5-HT 5-HT Amisulp Amisulp Ca+ 5-HT Amisulp Amisulp Amisulp Trp BH4 O2 5-HTP