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Pathway Description
Norethisterone Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-07-21
Last Updated: 2023-11-27
Norethisterone, also known as norethindrone, is a synthetic progestational hormone used for contraception, prevention of endometrial hyperplasia (hormone replacement therapy), and in the treatment of other hormone-related illnesses. This drug has the same action as endogenous progesterone but with greater potency. This drug acts by altering the cervical and endometrial function, as well as it inhibits the pituitary hormones, like the Follicle-stimulating hormone (FSH) and the Luteinizing hormone (LH) via binding to progesterone receptors that inhibits the Gonadotropin hormone-releasing hormone (GnRH) production in the hypothalamus. The low levels of LH and FSH result in the inhibition of the production of estrogen in the ovaries, thus inhibiting follicular maturation, ovulation, and corpus luteum development. Norethisterone has a low affinity for other steroid receptors, such as the androgen receptor and glucocorticoid receptor. Even if these affinities are low, it is thought that androgen receptor agonism is responsible for some of the adverse effects observed, like acne and serum lipid changes. This drug is administered as an oral tablet.
References
Norethisterone Pathway References
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Pubmed: 22935222
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