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Thrombin Proteinase- activated receptor 1 Guanine nucleotide- binding protein G(q) PLCB1 Protein kinase C Ras-related protein Rap-1A RIAM-Rap1-GTP complex Talin-1 Fibrinogen Glycoprotein IIb/IIIa Vorapaxar Vorapaxar Vorapaxar H2O Calcium DG PIP2 IP3 Glycoprotein IIb/IIIa Calcium Vorapaxar binds as an antagonist to proteinase-activated receptor 1 (PAR-1) Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Vorapaxar is administered orally and travels through the bloodstream Blood Vessel PAR-1 when activated leads to a cascade where glycoprotein IIb/IIIa signals platelet aggregation and activation. With PAR-1 inhibited by Vorapaxar this cascade does not occur and no platelets are activated
Melanosome Chloroplast Chloroplast Unknown Unknown GNAQ PLCB1 PRKCA RAP1A RAP1A TLN1 Unknown Unknown Vorapaxar Vorapaxar Vorapaxar Water DG PIP2 IP3 ITGA2B
GNAQ PLCB1 PRKCA RAP1A RAP1A TLN1 Vorap Vorap Vorap H2O Ca2+ DG PIP2 IP3 ITGA2B Ca2+ Vorapaxar binds as an antagonist to proteinase-activated receptor 1 (PAR-1) Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Vorapaxar is administered orally and travels through the bloodstream Blood Vessel PAR-1 when activated leads to a cascade where glycoprotein IIb/IIIa signals platelet aggregation and activation. With PAR-1 inhibited by Vorapaxar this cascade does not occur and no platelets are activated
Melanosome Chloroplast Chloroplast GNAQ PLCB1 PRKCA RAP1A RAP1A TLN1 Vorap Vorap Vorap H2O DG PIP2 IP3 ITGA2B