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D(2) dopamine receptor D(1A) dopamine receptor D(1B) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Acepromazine Acepromazine Ca+ Dopamine Dopamine Acepromazine Acepromazine Acepromazine L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi signaling cascade Gi Signaling Cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Acepromazine is a D1 and D2 receptor antagonist. D2 receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia ↓ Positive, negative and cognitive symptoms of schizophrenia and psychosis Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Passive Diffusion Acepromazine blocks dopamine receptors and depresses the reticular-activating system, resulting in sedation Acepromazine is taken orally and absorbed from the gastrointestinal tract
DRD2 DRD1 DRD5 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH Dopamine Calcium Acepromazine Acepromazine Calcium Dopamine Dopamine Acepromazine Acepromazine Acepromazine L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi signaling cascade Gi Signaling Cascade
DRD2 DRD1 DRD5 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Acetazi Acetazi Ca+ LDP LDP Acetazi Acetazi Acetazi L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi si c Gi Si C Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Acepromazine is a D1 and D2 receptor antagonist. D2 receptors in the mesolimbic pathway are responsible for producing the positive symptoms in schizophrenia ↓ Positive, negative and cognitive symptoms of schizophrenia and psychosis Excess dopamine in the brain triggers positive symptoms of schizophrenia Brain Mesolimbic pathway Blood vessel - blood brain barrier Passive Diffusion Passive Diffusion Acepromazine blocks dopamine receptors and depresses the reticular-activating system, resulting in sedation Acepromazine is taken orally and absorbed from the gastrointestinal tract