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Microtubule- associated protein 2 Microtubule- associated protein 1A Estramustine Transporter 17-beta- hydroxysteroid dehydrogenase type 6 Carbamidase Carbamidase Hydroxysteroid 17-beta dehydrogenase Estramustine Estramustine Estramustine Estramustine Estramustine NAD Estromustine NADH H+ Estrone Normustine Estradiol Normustine G2 - Growth, preparation for mitosis and DNA repair. Estramustine is absorbed in the intestine. It then goes in the blood network. After entering the cancerous cell, estramustine moves into the nucleus where it inhibits DNA but also some tubulin proteins. Secondly, it is postulated that estramustine binds to some nuclear proteins matrix. This causes some interferences in the DNA replication. Apoptosis The DNA strand breaks, the inhibition of the DNA replication and synthesis and the microtubules depolymerization all lead to the arrest of cell division in the G2/M phase of the cell cycle. This will cause the apoptosis. Prostate Cancerous Cell Hepatocyte Thirdly, estramustine causes strand breaks in the DNA in a dose-related manner. The mechanism of action is still unknown. Firslty, estramustine, because of its structure, binds to MAP2 and MAP1A (binding tubulin). This inhibits both proteins. This results in the depolimerization of the microtubules in the cancerous cells. Estramustine is highly metabolized to estrone. Although, the mechanism of action against the proliferation of cancerous cells is mostly accomplish by the unmetabolized estramustine. Cell Cycle M - Mitosis / Cell division G1 - Cell growth S - DNA Replication Estramustine blocks the cell division in the G2/M cell cycle.
Mitochondria Nucleus MAP2 MAP1A Unknown HSD17B6 Unknown Unknown HSD17B6 Estramustine Estramustine Estramustine Estramustine Estramustine NAD Estromustine NADH Hydrogen Estrone Normustine Estradiol Normustine
MAP2 MAP1A HSD17B6 HSD17B6 Estramu Estramu Estramu Estramu Estramu NAD Estro NADH H+ Estrone Normu Estdiol Normu G2 - Growth, preparation for mitosis and DNA repair. Estramustine is absorbed in the intestine. It then goes in the blood network. After entering the cancerous cell, estramustine moves into the nucleus where it inhibits DNA but also some tubulin proteins. Secondly, it is postulated that estramustine binds to some nuclear proteins matrix. This causes some interferences in the DNA replication. Apoptosis The DNA strand breaks, the inhibition of the DNA replication and synthesis and the microtubules depolymerization all lead to the arrest of cell division in the G2/M phase of the cell cycle. This will cause the apoptosis. Prostate Cancerous Cell Hepatocyte Thirdly, estramustine causes strand breaks in the DNA in a dose-related manner. The mechanism of action is still unknown. Firslty, estramustine, because of its structure, binds to MAP2 and MAP1A (binding tubulin). This inhibits both proteins. This results in the depolimerization of the microtubules in the cancerous cells. Estramustine is highly metabolized to estrone. Although, the mechanism of action against the proliferation of cancerous cells is mostly accomplish by the unmetabolized estramustine. Cell Cycle M - Mitosis / Cell division G1 - Cell growth S - DNA Replication Estramustine blocks the cell division in the G2/M cell cycle.
Mitochondria Nucleus MAP2 MAP1A HSD17B6 HSD17B6 Estramu Estramu Estramu Estramu Estramu NAD Estro NADH H2 Estrone Normu Estdiol Normu