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Pathway Description
Altretamine Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-08-08
Last Updated: 2023-11-27
Altretamine, also known as Hexalen, is a novel alkylating agent from the antineoplastic drug class. This drug is used as a palliative treatment for patients with persistent or recurrent ovarian cancer. The precise mechanism of action of the drug is still not completely understood. It is known that following administration, the molecule goes through N-demethylation by the cytochrome P450 monooxygenases in the liver. This generates carbinalamine as an intermediate leading after to the formaldehyde and smaller inactive compounds. When the carbinalamine losses its hydroxy group, it gives the iminium species. This last molecule is the one that probably binds to DNA.
This drug is administered as an oral capsule.
References
Altretamine Pathway References
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Pubmed: 2748347
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Pubmed: 15057824
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Pubmed: 11016631
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Pubmed: 15063809
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Pubmed: 11470993
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Pubmed: 15190123
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Pubmed: 2573390
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Pubmed: 2722762
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Pubmed: 11137287
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Pubmed: 11266076
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Pubmed: 11181494
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Pubmed: 3460094
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Pubmed: 3267210
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Pubmed: 8569713
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Pubmed: 7811260
Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, et al.: Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J Biol Chem. 1989 Jun 25;264(18):10388-95.
Pubmed: 2732228
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Pubmed: 11160876
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Pubmed: 11243885
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