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D(2) dopamine
receptor
D(3) dopamine
receptor
D(2) dopamine
receptor
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Sodium-
dependent
dopamine
transporter
Vesicle-
associated
membrane
protein 2
Aromatic-L-
amino-acid
decarboxylase
Tyrosine
3-monooxygenase
Dopamine
Ca
+
Lisuride
Cariprazine
Ca
+
Dopamine
Cariprazine
Cariprazine
Dopamine
L-Dopa
CO
2
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
Na
+
Na
+
Pyridoxal
5'-phosphate
Gi Signaling
Cascade
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Cariprazine increases
dopamine activity in the
brain
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Cariprazine is a partial
agonist of D2, D3 receptors.
Brain
Mesolimbic pathway
Blood vessel - blood brain
barrier
Passive Diffusion
Cariprazine has a high
affinity for D3 receptors
Cariprazine is administered
orally and absorbed from the
gastrointestinal tract
DRD2
DRD3
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
VAMP2
DDC
TH
Dopamine
Calcium
Lisuride
Cariprazine
Calcium
Dopamine
Cariprazine
Cariprazine
Dopamine
L-Dopa
Carbon dioxide
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
Sodium
Sodium
Gi Signaling
Cascade
DRD2
DRD3
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
VAMP2
DDC
TH
LDP
Ca
+
Lisurid
Carip
Ca
+
LDP
Carip
Carip
LDP
L-Dopa
CO
2
Tyr
BH4
O
2
BH3
H
2
O
Na
+
Na
+
Pyr-5'P
Gi Si C
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Cariprazine increases
dopamine activity in the
brain
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Cariprazine is a partial
agonist of D2, D3 receptors.
Brain
Mesolimbic pathway
Blood vessel - blood brain
barrier
Passive Diffusion
Cariprazine has a high
affinity for D3 receptors
Cariprazine is administered
orally and absorbed from the
gastrointestinal tract