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Amine oxidase
[flavin-
containing] B
Alpha-2A
adrenergic
receptor
Synaptic
vesicular amine
transporter
Sodium-
dependent
noradrenaline
transporter
Synaptic
vesicular amine
transporter
Sodium-
dependent
noradrenaline
transporter
Aromatic-L-
amino-acid
decarboxylase
Dopamine beta-
hydroxylase
Tyrosine
3-monooxygenase
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Catechol O-
methyltransferase
Pargyline
Norepinephrine
Norepinephrine
Norepinephrine
Norepinephrine
Pargyline
Pargyline
Pargyline
L-Dopa
Dopamine
CO
2
Ascorbic acid
O
2
Dehydroascorbic acid
H
2
O
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
3,4-Dihydroxymandelaldehyde
NAD
H
2
O
3,4-Dihydroxymandelic acid
NADH
H
+
S-Adenosylmethionine
Vanillylmandelic acid
S-Adenosylhomocysteine
H
2
O
O
2
NH
3
H
2
O
2
FAD
Magnesium
Gi/o signaling
cascade
Pyridoxal
5'-phosphate
Fe2+
Pyrroloquinoline
quinone
Copper
Post synaptic neuron
Norepinephrine is
synthesized from tyrosine
and stored in presynaptic
vesicles.
Synapse
Cytosol
Presynaptic Neuron
Cytosol
Postsynaptic Neuron
Diffusion
Blood-Brain Barrier
Pargyline is transported in
the neurons by the
noradenaline reuptake
transporter.
Pargylinee inhibits the
amine oxidase B. This
results in the decrease of
the metabolism of
norepinephrine.
The inhibition of this
enzyme will increase the
concentration in
norepinephrine in the
cytosol of the presynaptic
neuron.
Lower blood pressure
Norepinephrine activates
postsynaptic adrenergic
receptors alpha-2 which are
responsible for lowering the
blood pressure in the
sympathetic tone (in the
local and regional blood
network). This activation
also decreases the levels of
noradrenaline in the blood.
MAOB
ADRA2A
SLC18A2
SLC6A2
SLC18A2
SLC6A2
DDC
DBH
TH
ALDH3A1
COMT
Pargyline
Norepinephrine
Norepinephrine
Norepinephrine
Norepinephrine
Pargyline
Pargyline
Pargyline
L-Dopa
Dopamine
Carbon dioxide
Ascorbic acid
Oxygen
Dehydroascorbic
acid
Water
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
3,4-
Dihydroxymandelaldehyde
NAD
Water
3,4-
Dihydroxymandelic
acid
NADH
Hydrogen Ion
S-
Adenosylmethionine
Vanillylmandelic
acid
S-
Adenosylhomocysteine
Water
Oxygen
Ammonia
Hydrogen
peroxide
Gi/o signaling
cascade