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D(2) dopamine
receptor
Adenylate
cyclase type 2
Amine oxidase
[flavin-
containing] B
Synaptic
vesicular amine
transporter
Sodium-
dependent
dopamine
transporter
Sodium-
dependent
dopamine
transporter
Tyrosine
3-monooxygenase
Aromatic-L-
amino-acid
decarboxylase
Catechol O-
methyltransferase
Dopamine
Selegiline
cAMP
Dopamine
Dopamine
Dopamine
Selegiline
Selegiline
Selegiline
L-Tyrosine
Tetrahydrobiopterin
O
2
L-Dopa
Dihydrobiopterin
H
2
O
CO
2
S-Adenosylmethionine
3-Methoxytyramine
S-Adenosylhomocysteine
H
2
O
O
2
Homovanillin
H
2
O
2
NH
3
ATP
PP
i
Magnesium
FAD
Fe2+
Pyridoxal
5'-phosphate
Neuronal
Excitability
Magnesium
Post synaptic neuron
Synapse
Cytosol
Presynaptic Neuron
Cytosol
Postsynaptic Neuron
Diffusion
Blood-Brain Barrier
Selegiline is transported in
the neurons by the dopamine
reuptake transporter.
Since Parkinson's disease is
caused by low level of
dopamine in the substantia
nigra, the effect of the
drug brings the level of
dopamine to a normal and
higher level.
Dopamine activates the D2
(dopamine) receptors. This
causes the phosphorylation
of many proteins and the
decrease of the
concentration in cAMP. Low
levels of cAMP decreases
neuronal excitability in the
nigrostriatal pathway.
Synaptic Vesicle
Nigrostriatal pathway
Selegiline inhibits amine
oxidase B (MAO B) catalyzing
the metabolism of dopamine.
This results in higer levels
of dopamine in the neurons
cytosol.
DRD2
ADCY2
MAOB
SLC18A2
SLC6A3
SLC6A3
TH
DDC
COMT
Dopamine
Selegiline
cAMP
Dopamine
Dopamine
Dopamine
Selegiline
Selegiline
Selegiline
L-Tyrosine
Tetrahydrobiopterin
Oxygen
L-Dopa
Dihydrobiopterin
Water
Carbon dioxide
S-
Adenosylmethionine
3-
Methoxytyramine
S-
Adenosylhomocysteine
Water
Oxygen
Homovanillin
Hydrogen
peroxide
Ammonia
Adenosine
triphosphate
Pyrophosphate
Neuronal
Excitability