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Alpha-1A
adrenergic
receptor
Beta-1
adrenergic
receptor
Beta-2
adrenergic
receptor
Sodium-
dependent
noradrenaline
transporter
Synaptic
vesicular amine
transporter
Sodium-
dependent
noradrenaline
transporter
Synaptic
vesicular amine
transporter
Aromatic-L-
amino-acid
decarboxylase
Dopamine beta-
hydroxylase
Amine oxidase
[flavin-
containing] A
Tyrosine
3-monooxygenase
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Catechol O-
methyltransferase
Norepinephrine
Phentermine
Norepinephrine
Norepinephrine
Norepinephrine
Phentermine
Phentermine
L-Dopa
Dopamine
CO
2
Ascorbic acid
O
2
Dehydroascorbic acid
H
2
O
H
2
O
O
2
3,4-Dihydroxymandelaldehyde
H
2
O
2
NH
3
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
NAD
H
2
O
3,4-Dihydroxymandelic acid
NADH
H
+
S-Adenosylmethionine
Vanillylmandelic acid
S-Adenosylhomocysteine
Magnesium
Gq signaling
cascade
Gs signaling
cascade
FAD
Pyridoxal
5'-phosphate
Fe2+
Pyrroloquinoline
quinone
Copper
Post synaptic neuron
Norepinephrine is
synthesized from tyrosine
and stored in presynaptic
vesicles.
Synapse
Cytosol
Presynaptic Neuron
Cytosol
Postsynaptic Neuron
Diffusion
Blood-Brain Barrier
Suppression of Appetite
Phentermine is a
sodium-dependent
noradrenaline transporter
inhibitor. This activity
results in higher
concentrations of
noradrenaline in the
synapse.
Norepinephrine activates the
postsynaptic adrenergic
receptors (alpha and beta).
This provokes the satiety
feeling.
Lateral Hypothalamus
ADRA1A
ADRB1
ADRB2
SLC6A2
SLC18A2
SLC6A2
SLC18A2
DDC
DBH
MAOA
TH
ALDH3A1
COMT
Norepinephrine
Phentermine
Norepinephrine
Norepinephrine
Norepinephrine
Phentermine
Phentermine
L-Dopa
Dopamine
Carbon dioxide
Ascorbic acid
Oxygen
Dehydroascorbic
acid
Water
Water
Oxygen
3,4-
Dihydroxymandelaldehyde
Hydrogen
peroxide
Ammonia
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
NAD
Water
3,4-
Dihydroxymandelic
acid
NADH
Hydrogen Ion
S-
Adenosylmethionine
Vanillylmandelic
acid
S-
Adenosylhomocysteine
Gq signaling
cascade
Gs signaling
cascade