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Pathway Description
Erythromycin Anti-Bacterial Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-08-22
Last Updated: 2023-11-27
Erythromycin is a macrolide antibiotic used to treat bacterial infection, it binds to 23s ribosomal RNA which is part of the 50s subunit. Due to the binding, it inhibits the assembly of the 50s ribosomal subunit which is necessary for protein synthesis. It is administered orally and diffuses throughout the body. It is metabolized into N-desmethylerthromycin by the CYP3A4 enzyme during first-pass metabolism. Erythromycin should be taken on an empty stomach at least 30 minutes to 2 hours prior to a meal in order to increase absorption. Products that contain grapefruit should be avoided.
References
Erythromycin Anti-Bacterial Pathway References
Kanazawa S, Ohkubo T, Sugawara K: The effects of grapefruit juice on the pharmacokinetics of erythromycin. Eur J Clin Pharmacol. 2001 Jan-Feb;56(11):799-803. doi: 10.1007/s002280000229.
Pubmed: 11294369
Ogwal S, Xide TU: Bioavailability and stability of erythromycin delayed release tablets. Afr Health Sci. 2001 Dec;1(2):90-6.
Pubmed: 12789122
Houin G, Tillement JP, Lhoste F, Rapin M, Soussy CJ, Duval J: Erythromycin pharmacokinetics in man. J Int Med Res. 1980;8 Suppl 2:9-14.
Pubmed: 7429008
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