Neomycin is an antibiotic agent from the aminoglycoside family. It is administered as an oral tablet and as a topical ointment to treat bacterial infections. Neomycin is derived from Streptomyces fradiae by-products. There are three components A, B, and C, component B is the most active. This aminoglycoside is effective against gram-positive and gram-negative bacteria. It acts by binding to the 30S ribosomal subunit disrupting protein synthesis and inhibiting further translation. Specifically, this drug binds the 30S ribosomal protein S12. Due to its low absorption, overdosing is unlikely to occur, although a prolonged administration can cause the risk of neurotoxicity, ototoxicity, and nephrotoxicity in humans.

Neomycin Pathway References