Rolitetracycline, a broad-spectrum tetracycline antibiotic, is used for treatment when higher concentrations are required. Rolitetracycline passively diffuses through porin channels into bacterial cells and binds to the 30S ribosomal subunit. By binding to 30S subunit which prevents tRNA binding to mRNA ribosome complex and disrupting protein synthesis. Milk and dairy products should be avoided in order to optimize the absorption of rolitetracycline.

Rolitetracycline Pathway (new) References