
Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Paromomycin Action Pathway (new)
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-08-24
Last Updated: 2023-11-27
Paromomycin is a broad-spectrum aminoglycoside antibiotic, that inhibits bacterial synthesis. Paromomycin binds to the A site of the 30s subunit, causing misreading of amino acids and leading to defective polypeptide chains being produced causing bacterial death.
References
Paromomycin Pathway (new) References
Davidson RN, den Boer M, Ritmeijer K: Paromomycin. Trans R Soc Trop Med Hyg. 2009 Jul;103(7):653-60. doi: 10.1016/j.trstmh.2008.09.008. Epub 2008 Oct 23.
Pubmed: 18947845
Burgana A, Abellana R, Yordanov SZ, Kazan R, Perez Ortiz AM, Ramos CC, Hernandez CG, Rivero MM, Goncalves AQ, Padilla E, Perez J, Garcia-Puig R, Perez-Porcuna TM: Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment. Int J Parasitol Drugs Drug Resist. 2019 Dec;11:95-100. doi: 10.1016/j.ijpddr.2019.10.005. Epub 2019 Nov 11.
Pubmed: 31759244
Musa AM, Mbui J, Mohammed R, Olobo J, Ritmeijer K, Alcoba G, Muthoni Ouattara G, Egondi T, Nakanwagi P, Omollo T, Wasunna M, Verrest L, Dorlo TPC, Musa Younis B, Nour A, Taha Ahmed Elmukashfi E, Ismail Omer Haroun A, Khalil EAG, Njenga S, Fikre H, Mekonnen T, Mersha D, Sisay K, Sagaki P, Alvar J, Solomos A, Alves F: Paromomycin and Miltefosine Combination as an Alternative to Treat Patients With Visceral Leishmaniasis in Eastern Africa: A Randomized, Controlled, Multicountry Trial. Clin Infect Dis. 2023 Feb 8;76(3):e1177-e1185. doi: 10.1093/cid/ciac643.
Pubmed: 36164254
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
No Proteins Present
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
No Proteins Present
Downloads
Settings