PathBank

Pathway Description

Tedizolid Phosphate Action Pathway

Homo sapiens

Category:

Metabolite Pathway

Sub-Category:

Drug Action

Created: 2023-08-24

Last Updated: 2023-11-27

Tedizolid phosphate is an antibiotic, also known as Sivextro, used in the treatment of gram-positive bacterial infections. Tedizolid phosphate is a prodrug and is metabolized in the liver to its active form of Tedizolid. Tedizolid is part of the oxazolidinones class of antibacterials that are capable of inhibiting bacteria that are resistant to other antibiotics. The mechanism of action binds to the A site of the ribosome that interacts with the 23S rRNA subunit, which makes subsequent peptides nonfunctional protein.

References

Tedizolid Phosphate Pathway References

Ong V, Flanagan S, Fang E, Dreskin HJ, Locke JB, Bartizal K, Prokocimer P: Absorption, distribution, metabolism, and excretion of the novel antibacterial prodrug tedizolid phosphate. Drug Metab Dispos. 2014 Aug;42(8):1275-84. doi: 10.1124/dmd.113.056697. Epub 2014 May 29.

Pubmed: 24875463

Flanagan S, Fang E, Munoz KA, Minassian SL, Prokocimer PG: Single- and multiple-dose pharmacokinetics and absolute bioavailability of tedizolid. Pharmacotherapy. 2014 Sep;34(9):891-900. doi: 10.1002/phar.1458. Epub 2014 Jul 3.

Pubmed: 24989138

Roger C, Roberts JA, Muller L: Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones. Clin Pharmacokinet. 2018 May;57(5):559-575. doi: 10.1007/s40262-017-0601-x.

Pubmed: 29063519

Highlighted elements will appear in red.

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	Tedizolid
	Tedizolid phosphate

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