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Pathway Description
Chlortetracycline Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-08-24
Last Updated: 2023-11-27
Chlortetracycline is a tetracycline antibiotic commonly used for veterinary practice, that is commonly administered via topical ointment. Chlortetracycline acts by competing for the A site of the bacterial ribosome, by doing so the tRNA cannot bind to the site and thus no more amino acids cannot be added to the peptide chain. Ultimately leading to protein synthesis and halting growth and reproduction, as proteins cannot be synthesized that are necessary for bacteria cell reproduction.
References
Chlortetracycline Pathway References
Delsol AA, Anjum M, Woodward MJ, Sunderland J, Roe JM: The effect of chlortetracycline treatment and its subsequent withdrawal on multi-resistant Salmonella enterica serovar Typhimurium DT104 and commensal Escherichia coli in the pig. J Appl Microbiol. 2003;95(6):1226-34. doi: 10.1046/j.1365-2672.2003.02088.x.
Pubmed: 14632995
Macia E, Vazquez-Rojas M, Robiolo A, Fayad R, Abelanet S, Mus-Veteau I, Fontaine-Vive F, Mehiri M, Luton F, Franco M: Chlortetracycline, a Novel Arf Inhibitor That Decreases the Arf6-Dependent Invasive Properties of Breast Cancer Cells. Molecules. 2021 Feb 12;26(4):969. doi: 10.3390/molecules26040969.
Pubmed: 33673086
Qiu W, Chen B, Tang L, Zheng C, Xu B, Liu Z, Magnuson JT, Zhang S, Schlenk D, Xu EG, Xing B: Antibiotic Chlortetracycline Causes Transgenerational Immunosuppression via NF-kappaB. Environ Sci Technol. 2022 Apr 5;56(7):4251-4261. doi: 10.1021/acs.est.1c07343. Epub 2022 Mar 14.
Pubmed: 35286074
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