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Pathway Description
Omadacycline Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2023-08-24
Last Updated: 2023-11-27
Omadacycline is a tetracycline antibiotic also known as Nuzyra, commonly used to treat bacterial pneumonia. It acts by binding to the 30S ribosomal subunit blocking protein synthesis and disrupting bacterial function leading to cell death. Omadacycline should be taken on an empty stomach and multivalent ions and antacids should be avoided whilst taking omadacycline.
References
Omadacycline Pathway References
Zhanel GG, Esquivel J, Zelenitsky S, Lawrence CK, Adam HJ, Golden A, Hink R, Berry L, Schweizer F, Zhanel MA, Bay D, Lagace-Wiens PRS, Walkty AJ, Lynch JP 3rd, Karlowsky JA: Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent. Drugs. 2020 Feb;80(3):285-313. doi: 10.1007/s40265-020-01257-4.
Pubmed: 31970713
Gallagher JC: Omadacycline: A Modernized Tetracycline. Clin Infect Dis. 2019 Aug 1;69(Suppl 1):S1-S5. doi: 10.1093/cid/ciz394.
Pubmed: 31367739
Vacalis S, Brunton S, Gindi J: Omadacycline in Skin Infections and Pneumonia: A Review of the Evidence. J Fam Pract. 2022 Jun;71(5 Suppl):S10-S21. doi: 10.12788/jfp.0424.
Pubmed: 35776862
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