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5-
hydroxytryptamine
receptor 7
5-
hydroxytryptamine
receptor 3A
Sodium-
dependent
serotonin
transporter
5-
hydroxytryptamine
receptor 1A
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Synaptic
vesicular amine
transporter
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Ca
+
Serotonin
Serotonin
Vortioxetine
Vortioxetine
Ca
+
Serotonin
Vortioxetine
Vortioxetine
Vortioxetine
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
Na
+
Na
+
Fe2+
Pyridoxal
5'-phosphate
GPCR signaling
pathway
PLC signalling
pathway
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ Negative symptoms of
schizophrenia
Serotonin is synthesized and
stored in synaptic vesicles
at the nerve terminal
Vortioxetine binds to 5HT2A
and 5HT7 receptors where it
acts as a functional
antagonist to reduce
negative symptoms of
schizophrenia
↑Cognitive Improvement
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
Passive Diffusion
Antidepressant effects
passive diffusion
Vortioxetine is a serotonin
modulator and stimulator
with multimodal mechanism of
action towards the serotonin
neurotransmitter system.
Vortioxetine is administered
orally
It is also a partial agonist
to 5-HT1A and 5-HT1B
receptors and an inhibitor
to serotonin transporter
HTR7
HTR3A
SLC6A4
HTR1A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
TPH1
DDC
Calcium
Serotonin
Serotonin
Vortioxetine
Vortioxetine
Calcium
Serotonin
Vortioxetine
Vortioxetine
Vortioxetine
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Sodium
Sodium
GPCR signaling
pathway
PLC signalling
pathway
HTR7
HTR3A
SLC6A4
HTR1A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
TPH1
DDC